Comparative hematological and histopathological toxicity of two potential bio-insecticides against albino rats

Ivermectin [1.8% E.C] and spinosad [24% SC] are bioinsecticides produced by fermentation of some bacteria species. These compounds were selected to evaluate their haematological and histopathological toxicities against albino rats. The tested compounds were orally administrated to rats at 1/10 LD[50] every three days for one month period. Hemoglobin value [HB], red blood cells [RBC], white blood cells [WBC] and platelets [PLT] counts, gamma glutamyl transferase [gammaGT] were determined in addition to histopathological examinations for liver, spleen and kidney. In general, both compounds induced significant changes in HB value, RBC, WBC, PLT counts, and gammaGT activity after 30 days from treatment. Ivermectin caused significant rise in creatinine level at the same period. Histopathological examination showed disturbance in hepatic lobules, inflammatory infiltration, and pyknotic and karyolitic nuclei in hepatocytes. Kidney exhibited lobulated glomeruli and degenerative tubules, but interstitial hemorrhagic areas were noticed in spleen. Although the tested compounds are biopesticides, obtained data revealed that both compounds caused undesirable effects on experimental animals, so we conclude not to use them on plants during fruit stage or on fresh vegetables

Haematological side effect of Helicobacter pylori eradication

The effect of Helicobacter pylori infection on systemic disorders is not well understood. This study was to evaluate the effect of H. pylori eradication on blood count, differential leucocytic count and RBCs indices. In this study, atotal of 115 H. pylori positive patients underwent eradication triple therapy for one week, with cured 100 patients. Complete blood count, RBCs indices and differential leucocytic count were analyzed before 2 and 12 weeks after eradication for the cured patients. The results showed that two weeks after H. pylori eradication, platelets count significantly increased but total leucocytic counts and neutrophils were significantly reduced. After three months, RBCs count, Hb concentration, MCV and MCHC were significantly increased, but lymphocytic counts was significantly reduced