RESUMEN
Purines are reported to be potent anti-epileptic agents as well as showing anti-anginal and anti-inflammatory activity[1]. The most important natural occurrence of purines is in the nucleotides and nucleic acids; compounds which perform some of the most crucial functions in fundamental metabolism. The chemotherapeutic uses of purines and purine analogues have prompted tremendous efforts towards their synthesis, both in academia and in the pharmaceutical industry[2]
Asunto(s)
Purinas/síntesis química , Anticonvulsivantes , Antiinflamatorios , Nucleótidos , Ácidos Nucleicos , Industria FarmacéuticaRESUMEN
A novel synthesis of condensed carbocyclic purine analogues via reaction of amino-diazoles and amino-triazoles with sodium salts of 2-[hydroxyl-methylene]-1-cycloalkanones was reported and the synthetic potential of the method was demonstrated in this work. The results of the study were given and discussed