Detection of ranitidine by thin layer chromatography technique: A case study.

In one case, viscera of a lady was received, who expired following injection given by doctor in urban area. After conducting elaborate analysis data were found similar to Ranitidine. Hence, it was thought worthwhile to concentrate on this drug .The present paper describes the extraction of Ranitidine from visceral material and its identification by thin layer chromatography using suitable solvent system and potassium iodo bismuthate as locating reagent.

Centellografía en el desarrollo faramcéutico: estudios in vitro e in vivo de comprimidos de ranitidina / Scintigraphy in pharmaceutical development stage in vitro e in vivos studies of ranitidina tablets

El presente trabajo tiene como objetivo evaluar la utilidad de los estudios centellográficos in vitro e in vivo en el desarrollo de una formulación farmacéutica. Se eligio como trazador del proceso el radiofármaco 99mtc-ácido dietilentriaminopentaacético, que se incorporó a 4 formulaciones (f1 a f4) de comprimidos de ranitidina. Se llevaron a cabo estudios de estabilidad del radiofármaco en polvos, granulados y comprimidos. Las formulaciones en las cuales se verificó su estabilidad durante 24 horas (f2 y f4) fueronutilizadas para ensayos in vitro de disolución y desintegración y estudios en 6 voluntarios sanos. La desintegración in vitro e in vivo fué monitoreada por centellografía gamma. El radiofármaco presentó diferentes cinéticas de disolución a partir de f2 y f4, siendo las respectivas constantes que para la ranitidina en cada formulación en estudio. La centellografía permitió establecer una correlación entre las constantes de desintegración in vitro e in vivo. Esto permitiría predecir el comportamiento en el tracto gastro-intestinal de cada formulación a partir de la desintegración in vitro

Quantitative determination of cimetidine and ranitidine using n-bromosuccinimide [NBS]

A simple and accurate titrimetric method was developed for the determination of cimetidine and ranitidine. It involved direct titration of the mentioned drugs with NBS using methyl red as indicator. The stoichiometry for each drug was ascertained. The reaction pathways and products between NBS, cimetidine and ranitidine hydrochloride were suggested. The method was applied successfully for the determination of the investigated drugs in their pharmaceutical dosage forms. The validity of the method was checked by applying the st and ard addition technique. Compared with the official USP XXII assay of cimetidine, the method is simple, rapid and highly sensitive