Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Añadir filtros








Intervalo de año
1.
Iranian Journal of Public Health. 2011; 40 (2): 6-10
en Inglés | IMEMR | ID: emr-109695

RESUMEN

Molecular components of the dopamine receptor [DRD3] play an important role in the pathophysiology of schizophrenia [SCZ]. Previous studies have demonstrated an association between the DRD3 Ser9Gly polymorphism and SCZ but the results have been inconclusive. In this study, we investigated this controversial association between the Ser9Gly [A/G] polymorphism and SCZ using Malay cases-control [261 cases/157 controls] samples. PCR-RFLP was performed to genotype the distribution of the DRD3 Ser9Gly polymorphism. Both healthy control and SCHZ patient groups were in of Hardy-Weinberg equilibrium for the analyzed genetic variability. There was a significant association between the genotype distribution DRD3 polymorphisms and SCZ [chi[2]= 9.359; df= 2; P= 0.009]. We believe that further studies are required to examine the association between others dopamine-related genes and the behavioral phenotypes of SCZ


Asunto(s)
Humanos , Masculino , Femenino , Receptores de Dopamina D3/genética , Polimorfismo Genético , Serina , Glicina , Reacción en Cadena de la Polimerasa , Polimorfismo de Longitud del Fragmento de Restricción , Genotipo , Estudios de Casos y Controles
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA