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Mem. Inst. Oswaldo Cruz ; 110(6): 755-759, Sept. 2015. tab
Artículo en Inglés | LILACS, SES-SP | ID: lil-763097

RESUMEN

The aim of the present study was to assess the prevalence of Haemophilus influenzaetype b (Hib) nasopharyngeal (NP) colonisation among healthy children where Hib vaccination using a 3p+0 dosing schedule has been routinely administered for 10 years with sustained coverage (> 90%). NP swabs were collected from 2,558 children who had received the Hib vaccine, of whom 1,379 were 12-< 24 months (m) old and 1,179 were 48-< 60 m old. Hi strains were identified by molecular methods. Hi carriage prevalence was 45.1% (1,153/2,558) and the prevalence in the 12-< 24 m and 48-< 60 m age groups were 37.5% (517/1,379) and 53.9% (636/1,179), respectively. Hib was identified in 0.6% (16/2,558) of all children in the study, being 0.8% (11/1,379) and 0.4% (5/1,179) among the 12-< 24 m and 48-< 60 m age groups, respectively. The nonencapsulate Hi colonisation was 43% (n = 1,099) and was significantly more frequent at 48-< 60 m of age (51.6%, n = 608) compared with that at 12-< 24 m of age (35.6%, n = 491). The overall resistance rates to ampicillin and chloramphenicol were 16.5% and 3.7%, respectively; the co-resistance was detected in 2.6%. Our findings showed that the Hib carrier rate in healthy children under five years was very low after 10 years of the introduction of the Hib vaccine.


Asunto(s)
Humanos , Lactante , Preescolar , Portador Sano/inmunología , Infecciones por Haemophilus/prevención & control , Vacunas contra Haemophilus/uso terapéutico , Haemophilus influenzae tipo b/inmunología , Nasofaringe/microbiología , Resistencia a la Ampicilina/inmunología , Cápsulas Bacterianas/inmunología , Brasil/epidemiología , Portador Sano/microbiología , Resistencia al Cloranfenicol/inmunología , Estudios Transversales , Infecciones por Haemophilus/epidemiología , Haemophilus influenzae tipo b/clasificación , Esquemas de Inmunización , Vacunación Masiva , Pruebas de Sensibilidad Microbiana , Reacción en Cadena de la Polimerasa , Prevalencia , Encuestas y Cuestionarios
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