Types of the endoneurial oedema after the crush injury of the peripheral nerve in albino rat

This study included 20 male albino rats; the left common peroneal nerves of 18 rats were subjected to crush injury, while 2 rats were used as a control. The common peroneal nerves were exposed and some of their parts distal to the crush injury were taken. The specimens were prepared for study by electron microscope. The results showed that the endoneurial edema was distributed all over the endoneurium, especially in the sub-perineurial and perivascular areas forming sub- perineurial and perivascular edema. The axoplasm of the nerve axons showed edema fluid causing a separation of its contents of the cell organelles, intra-axonal edema. Also, the mitochondria became swollen with ill-defined internal cristae, intra-mitochondrial edema. The endothelial cells of the endoneurial blood vessels became partially swollen due to internal edema. The perineurium also became thick and edematous due to the presence of fluid between its layers, intra-perineurial edema

Morphological changes of tissues after extensive soft tissue injury / 法医学杂志

OBJECTIVE@#To study the pathological morphological changes for diagnosing the cause of death of extensive soft tissue injury or crush syndrome.@*METHODS@#The tissues were stained by HE and IHC.@*RESULTS@#(1) The Mb positive rate was 60%, 75%, 95% respectively. (2) Both the HSP70 positive rate of hearts and brains were 90%.@*CONCLUSION@#(1) The animal model of broad soft tissue injury was established. (2) Accumulated the pathological morphological data for diagnosing the cause of death of extensive soft tissue injury or crush syndrome.