Uso de psicofármacos y riesgo de apnea del sueño en pacientes internados en hospital general / Psychotropic drugs and obstructive sleep apnea risk use in hospitalized medical patients

RESUMEN: Se realizó un estudio descriptivo observacional, de corte transversal, con el objetivo de identificar la asociación del consumo de psicofármacos y el aumento del riesgo de padecer apnea obstructiva del sueño (A.O.S.), en pacientes internados y bajo tratamiento con psicofármacos en Hospital General (Hospital Pasteur, Montevideo, Uruguay) durante julio-septiembre de 2019. Se aplicó el cuestionario STOP BANG, hallándose riesgo elevado de A.O.S en el 59,4% de la muestra, del cual 75,6% corresponde al sexo masculino y el 24,4% corresponde al sexo femenino. El riesgo elevado para A.O.S fue: 54,3% para pacientes en tratamiento con un solo psicofármaco y 71,4% con dos. El grupo de antipsicóticos fue el que se asoció con mayor frecuencia al riesgo elevado de A.O.S.

SUMMARY A cross-sectional study was conducted with the objective of identifying the link between psychotropic medications and an increased risk of suffering from obstructive sleep apnea (OSA) in patients under treatment with psychotropic medication who were hospitalized in General Hospital (Hospital Pasteur, Montevideo, Uruguay) during the July-September 2019 period. The STOP BANG questionnaire was applied, elevated risk of OSA was found in 59.4% of the sample, of which 75.6% were male, while 24.4% were female. The elevated risk of OSA was: 54.4% for patients under treatment with a single psychotropic medication and 71.4% for patients under treatment with two psychotropic medications. Antipsychotics were the most frequently group of psychotropic drugs linked to an elevated OSA risk.

effect of opium on polysomnographic findings in patients with sleep apnea

Many reports are available about the increasing rate of mortality due to overuse of opioids. It has been suggested that sleep apnea can be a cause of mortality because of overuse of opioids. Opium use is common in Iran. This study aimed to assess the effect of opium on polysomnographic findings in opium addicts with sleep apnea syndrome. In this prospective case-control study, 50 opium addicts with sleep apnea were compared and matched for age, sex and body mass index with 50 non-addict patients with sleep apnea to determine the effect of opium on sleep disorders and polysomnographic findings. Sleep stages, apneas, hypopneas and desaturation were evaluated and recorded for participants in both groups. Data were analyzed and compared using SPSS version 15 software. There were significant differences between the two groups in sleep efficiency [P-value=0.00], apnea/hypopnea index [0.02], hypopnea [P-value=0.00], desaturation [P-value=0.01], sleep latency to stage 1[P-value=0.00] and central apnea [P-value=0.00] but no difference was detected for obstructive apnea [P-value=0.48]. Opium can increase central apnea, apnea-hypopnea index and desaturation in opium addicts compared with non-addicts