RESUMEN
Background: Historical and anthropological data suggest the presence of descendents of Changos, Cuncos, Chonos and Yamanas, South American indian populations, in certain Chilean coastal villages. Aim: To assess the degree of South American indian admixture in Chilean coastal villages using protein markers, to complete the assessment of human biological diversity in Chile. Subjects and methods: AB0, Rh, MNS, Duffy and Kidd blood group systems were assessed in 47, 48, 55 and 24 individuals from Paposo, Carelmapu, Laitec and Ukika respectively. Phenotypic and gene frequencies were calculated. The degree of South American indian admixture was estimated from the AB0*0 allele and Rh*dce haplotypes. Results: High frequencies of AB0*0, Fy*a, Jk*b alleles, Dce and Ms haplotypes were found in all villages, consistent with the pattern expected for South AmericanAboriginal populations. The highest presence of South American indian admixture was present in Laitec with 80 per cent and in Ukika with 74 per cent. The figures for Paposo and Carelmapu were 60 and 65 per cent respectively. Conclusions: Accordin g to South American indian admixture estimates, the genetic isolation of coastal populations is lower than that of inland subjects, suggesting thatsea proximity facilitates gene flow
Asunto(s)
Humanos , Masculino , Femenino , Genética de Población , Marcadores Genéticos , Dorso , Frecuencia de los Genes/genética , Población Rural , Sistema del Grupo Sanguíneo ABO/aislamiento & purificación , Sistema del Grupo Sanguíneo de Kidd/aislamiento & purificación , Sistema del Grupo Sanguíneo Duffy/aislamiento & purificación , Sistema del Grupo Sanguíneo MNSs/aislamiento & purificación , Sistema del Grupo Sanguíneo Rh-Hr/aislamiento & purificaciónAsunto(s)
Humanos , Femenino , Embarazo , Células Sanguíneas/clasificación , Células Sanguíneas/fisiología , Sangre Fetal , Edad Gestacional , Intercambio Materno-Fetal , Diagnóstico Prenatal , Aneuploidia , Anomalías Congénitas , Eritroblastos , Linfocitos , Procesos de Determinación del Sexo , Sistema del Grupo Sanguíneo Rh-Hr/inmunología , Sistema del Grupo Sanguíneo Rh-Hr/aislamiento & purificación , TrofoblastosRESUMEN
This work describes the genetic composition of atacameños from San Pedro de Atacama. The results show that a) the contribution of non-indigenous genes is relatively low, in relation to the spanish inmigration period. b) the Hardy-Weinberg genetics disequilibrium for MNSs system should have biological implications. c) the variant for esterasa D enzyme may be the same found in other chilean populations