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Yonsei Medical Journal ; : 851-855, 2011.
Artículo en Inglés | WPRIM | ID: wpr-182767

RESUMEN

IL-10 production by CD19(+)CD5(+) B cells was investigated, by determining the expression levels of CD19, a classical B cell marker. Peripheral mononuclear cells were stained with fluorescence-conjugated anti-CD5, anti-CD19, anti-IL-10, and Annexin V. Interestingly, IL-10-producing B cells were found to be localised within the CD19(low)CD5(+) B cell subset. Apoptotic changes were also observed mainly in CD19(low) cells among B cells. Thus, CD5(+) B cells should be classified as CD19(high) and CD19(low) cells, and the immunological significance of CD19 for the IL-10 production by CD5(+) B cells requires further studies.


Asunto(s)
Humanos , Antígenos CD19/metabolismo , Antígenos CD5/metabolismo , Apoptosis/inmunología , Subgrupos de Linfocitos B/citología , Separación Celular , Citometría de Flujo , Interleucina-10/biosíntesis
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