RESUMEN
BACKGROUND: Down’s syndrome is an important congenital chromosomal disorder that can be seen around the world. The antenatal screening for this disorder is an important processing in present obstetrics. OBJECTIVE: Due to the concept of first do no harm, the use of noninvasive test is recommended. The triple marker screening test has been introduced for a few years and acceptable for its effi cacy. RESULT: However, an important concern is on its costeffectiveness. Here, the author analyze and present the cost-effectiveness of the triple markers serum screening for Down’s syndrome in Thai setting. CONCLUSION: According to this work, the cost per effectiveness of triple markers serum screening is slightly lower than standard amniocentesis test.