Sulbenicilina sodica en el tratamiento de infecciones severas. / Sodium solbenicillin in the treatment of severe infections

Una de las principales causas de ingreso y defuncion en las Unidades de Cuidados Intensivos son los procesos infecciosos en su mayoria causados por germenes gramnegativos, particularmente Escherichia coli.Pseudomonas y Proteus. En el presente estudio se trato de demostrar el efecto terapeutico de la sulbenicilina sodica en pacientes infectados por estos germenes y la buena tolerancia o posible alteracion de las funciones hepaticas o renales.Se valoraron 30 pacientes, de los cuales 25 cursaban con infeccion grave sin estado de hipoperfusion: la respuesta anti-bacteriana y terapeutica se catalogo de excelente por la evolucion clinica, de laboratorio y gabinete. Sin embargo, en cinco pacientes con falla organica multiple, a pesar de la negativizacion de los cultivos, la muerte fue inevitable, lo cual indica que el control de la bacteremia, aunque es muy importante, no detiene el proceso citoquimico alterado en la hipoperfusion celular

Clinical Observation of Sulfobenzylpenicillin(Sulbencillin) in Urinary Tract Infection / 대한비뇨기과학회지

The effectiveness of Sulfobenzylpenicillin in the treatment of urinary tract infection was evaluated in the Department of Urology, Seoul National University Hospital during the period from May to November, 1973. Our clinical study was performed on the 28 patients who visited the outpatients clinic and admitted to the ward. These patients were studied by bacterioscopy with Gram's method of staining. and culture in blood agar plate and chocolate agar plate In this studies. the causative organisms were divided into 8 groups; E. coli (5), coagulase positive staphylococcus (5), pseudomonas (2), Corynebacterium spp. (1), a-hemolytic etreptococcus (2), N. Gonorrheae (10), Proteus (2) and KIebsiella (1). The dosage schedule was 1 gm. of Sulfobenzylpenicillin at intervals of 12 hours for consecutive 5 days in gonococcal urethritis and nongonococcal urethritis. But in upper urinary tract infections and post-operative infections, it lasted for 7 to 10 days or more. And following results were obtained. Effectiveness on Urological diseases 1) Gonococcal urethritis; Satisfactory clinical results were obtained with Sulfobenzylpenicillin for five days. Results were excellent in 5 cases, good in 4 cases and negative effect in 1 case. 2) Non-gonococcal urethritis; In this group, the therapeutic results were favorable in 90% of all cases. (excellent-4, good-5, fail-l) 3) Urethral stricture and fistula (2 cases); AII cases were responded to the Sulbenicillin. 4) Cystitis including Prostatism; Two of three cases were caused by E. coli and they had a good response to sulbenicillin. 5) Two cases of pyelonephritis and two cases of postoperative infections were studied with sulbenicillin and more than 60% of cases were effective with sulbenicillin. Side effects were not remarkable but in a few cases who received intramuscular injection, pain on the injection site was noticed.In summary, this new semi-synthetic penicillin is considered to be a useful chemotherapeutic weapon against a variety of infection in the urological field including those due to Gram negative bacilli such as pseudomonas and proteus sp.