A new antiviral isoquinoline alkaloid from Thalictrum glandulosissimum / 中国中药杂志

A new isoquinoline alkaloid(1) has been isolated from the whole plant of Thalictrum glandulosissimum by using various chromatographic techniques, including silica gel, sephadex, MCI-gel resin, and RP-HPLC, and its structure was determined as 1-(6-hydroxy-7-methylisoquinolin-1-yl) ethantone by physicochemical properties and spectroscopic data. This compound was evaluated for anti-tobacco mosaic virus(TMV) activity. The results showed that it had prominent anti-TMV activity with inhibition rates of 28.4%. This rate was closed to that of positive control.

Evaluation of antibacterial activities of some medicinal plants from north-West Iran

Aim of the present study was to screen the antibacterial activities of some medicinal plants extracts traditionally used in Azarbaijan area [Iran]. Thirty-six extracts obtained from different parts of ten plants including Tanacetum balsam ita L. [Copmositae], Muscari caucasicum Baker [Hyacinthaceae], Equisetum arvense L. [Equisetaceae], Achillea millefollum L. [Copmositae], Stachys fruticulosa M. Bieb. [Labiatae], Stachys schtschegleevii Sons. ex, Grossh. [Labiatae], Salvia sahendica Boiss and Buhse [Labiatae], Phlomis caucasica Rech. f. [Labiatae], Etchium italicum L. [Boraginaceae] and Thalictrum minus L. [Ranunculaceae] from north-west Iran with traditional medicinal use were examined for their antibacterial activities against some Gram-negative strains such as Escherichia coli, Pseudomonas aeruginosa, Salmonella paratyphi and Serratia marcescens, also, Gram-positive strains of Staphylococcus aureus, Micrococcus luteus, Staph. epidermidis, Streptococcus pneumoniae and Bacillus cereus. The filter paper disc diffusion method as well as broth serial dilution technique were applied to screen the antibacterial efficacy of the extracts and determination of minimum inhibitory values. Results indicated that the majority of tested plant extracts had antibacterial activity at least against one of the selected bacteria, with the exception of Muscari caucasicum. Methanol extract of the aerial part of Thalictrum minus L. [Ranunculaceae] showed the most potent antibacterial activity against Staph. Aureus with MIC value of 0.3125 mg/ml. The results of this study show that most of the studied plants are potentially a good source of antimicrobial agents and support the traditional applications of some of the tested plants

Review of bioactivities of natural cycloartane triterpenoids / 中国中药杂志

Cycloartane triterpenoids, which exist widely in nature, are mainly distributed in Astragalus (Leguminosae) species, Trib. Cimicifuga (Ranunculaceae) and Thalictrium (Ranunculaceae) species and possess various bioactivities. Along with the development of isolation techniques of phytochemistry, more and more this kind of compounds are isolated and identified. However, bioactivity researches on the compounds are relatively lagged behind. Most researches are still in screening level, deficient in mechanism elucidation, short of action proven in vivo and SAR analysis. The author summarized the bioactivity of this kind of compounds from all aspects: anti-tumor, anti-virus, antibacterial, anti-inflammation, immune-regulatory, cardiovascular system, hepatic protection and so forth. This will be benefit for the further research and development of the compounds.