RESUMEN
5-bromo-6-methoxy-5,6-dihydrouridine and its 2-thioanalogue were allowed to react with some substituted guanidine tautomers and alpha- mercapto-beta-phenylacrylic acid. The products are 5,6-cyclized derivatives of both of uridine and 2-thiouridine
Asunto(s)
Tiouridina/química , Guanidinas/química , Compuestos de Sulfhidrilo/química , Guanidinas/análogos & derivados , Compuestos de Sulfhidrilo/análogos & derivadosRESUMEN
Uridine and 4-thiouridine were converted into the corresponding 2,3-o-isopropylidene-5-thiocyanato derivatives. Then, each resulted derivative was reacted individually with both of ethyl alpha- chloroacetoacetate, ethyl alpha-bromobenzoylacetate and ethyl bromo pyruvate. Furthermore, these 5-thiocyanato products were transformed into the corresponding 5-mercapto analogues. The produced analogues were undergo ring formation to give the corresponding 4,5-cyclized pyrimidine derivatives
Asunto(s)
Tiouridina/química , Ésteres/química , Uridina/análogos & derivados , Tiouridina/análogos & derivadosRESUMEN
The present paper described work directed towards reactions of both of 2',3',5'-tri-O-acetyl uridine and its 2-thioanlogue with either of 2H- pyran-2-one, 4,6-dimethyl-2H-pyran-2-one and 2,3-bis [dibromomethyl] benzene to afford cycloaddition products