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Clinics ; 64(3): 235-244, 2009. graf, tab, ilus
Artículo en Inglés | LILACS | ID: lil-509429

RESUMEN

OBJECTIVE: This study examined the effects of palm oil tocotrienol-rich fractions on streptozotocin-induced diabetic rats. METHODS: Animals were divided into three groups: (i) normal non-diabetic (NDM), (ii) diabetic treated (tocotrienol-rich fractions - TRF) and (iii) diabetic untreated (non-TRF). The treatment group received oral administration of tocotrienol-rich fractions (200 mg/kg body weight) daily for eight weeks. The normal non-diabetic and the diabetic untreated groups were fed standard rat feed. Blood glucose and lipid profiles, oxidative stress markers and morphological changes of the thoracic aorta were evaluated. RESULTS: Tocotrienol-rich fractions treatment reduced serum glucose and glycated hemoglobin concentrations. The tocotrienol-rich fractions group also showed significantly lower levels of plasma total cholesterol, low-density lipoprotein cholesterol, and triglyceride, as compared to the untreated group. The tocotrienol-rich fractions group had higher levels of high-density lipoprotein cholesterol, as compared to the untreated group. Superoxide dismutase activity and levels of vitamin C in plasma were increased in tocotrienol-rich fractions-treated rats. The levels of plasma and aorta malondealdehyde + 4-hydroxynonenal (MDA + 4-HNE) and oxidative DNA damage were significant following tocotrienol-rich fractions treatment. Electron microscopic examination showed that the normal morphology of the thoracic aorta was disrupted in STZ-diabetic rats. Tocotrienol-rich fractions supplementation resulted in a protective effect on the vessel wall. CONCLUSION: These results show that tocotrienol-rich fractions lowers the blood glucose level and improves dyslipidemia. Levels of oxidative stress markers were also reduced by administration of tocotrienol-rich fractions. Vessel wall integrity was maintained due to the positive effects mediated by tocotrienol-rich fractions.


Asunto(s)
Animales , Masculino , Ratas , Antioxidantes/administración & dosificación , Aorta Torácica/efectos de los fármacos , Diabetes Mellitus Experimental/sangre , Estrés Oxidativo/efectos de los fármacos , Aceites de Plantas/administración & dosificación , Tocotrienoles/administración & dosificación , Aorta Torácica/ultraestructura , Glucemia/efectos de los fármacos , Colesterol/sangre , Suplementos Dietéticos , Diabetes Mellitus Experimental/patología , Microscopía Electrónica de Transmisión , Músculo Liso Vascular/efectos de los fármacos , Músculo Liso Vascular/ultraestructura , Ratas Sprague-Dawley , Estreptozocina
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