RESUMEN
Tonsillectomy is defined as the surgical excision of the palatine tonsils. This single blind prospective study of [200] patients underwent tonsillectomy in Al- Rizgary Teaching Hospital-Erbil- Iraq from February 2006 through June 2006.The main aim of this study is to evaluate the effect of post-tonsillectomy amoxicillin in preventing infection and secondary haemorrhage. Our patient's ages ranged from 2.5 years-55 years and were randomly divided postoperatively into two equal groups. The first group received amoxicillin antibiotic with analgesic paracetamol up to one week postoperatively. The second group received only paracetamol for one week. All tonsillectomy surgeries were done by cold knife dissection method. In the first group no one developed complications neither postoperative infection nor secondary hemorrhage, whereas in the second group who received only paracetamol, 4 patients [4%] had features of infections post operatively with another 2 patients [2%] developed secondary hemorrhage controlled conservatively. The above results showed no significant effect of post-tonsillectomy antibiotic to prevent infection or delayed bleeding
Asunto(s)
Humanos , Masculino , Femenino , Tonsilectomía/efectos adversos , Complicaciones Posoperatorias/prevención & control , Profilaxis Antibiótica , Pruebas de Sensibilidad Microbiana , Hospitales de Enseñanza , Método Simple Ciego , Tonsila Palatina/metabolismo , Estudios Prospectivos , Distribución AleatoriaRESUMEN
To investigate the role of cyclin B1 and cdc2 in the pathogenesis and progression of malignant lymphoma, 68 cases of nodal non-Hodgkin's lymphoma were examined about the expression of cyclin B1 and cdc2 along with p53 and Ki-67 by immunohistochemical method. The correlation of their expression with various clinicopathologic findings was also analyzed. Cyclin B1 and cdc2 were diffusely expressed in 39 cases (57.4%) and 54 cases (79.4%) out of 68 cases studied, respectively. The mean labeling indices of cyclin B1 and cdc2 in malignant lymphoma were 31.9% and 68.0%, respectively. In normal lymphoid tissues, cyclin B1 and cdc2 were expressed predominantly in the germinal center with mean labeling indices of 13.9% and 28.3%, respectively. The correlation between the expression of cyclin B1 and cdc2 was noted (p=0.013). The expression of Ki-67 was correlated with that of cyclin B1 (p=0.023) and marginally correlated with that of cdc2 (p=0.056). The expression of cdc2 and p53 in complete remission group to chemotherapy was lower than that of progressive disease group (p=0.047, p=0.049). In multivariate analysis, the clinical stage alone showed significance on overall survival (p=0.049). In conclusion, cyclin B1 and cdc2 appeared to be involved in the genesis or progression of malignant lymphoma and cdc2 can be a useful marker for response to chemotherapy.
Asunto(s)
Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proteína Quinasa CDC2/biosíntesis , Ciclina B/biosíntesis , Ciclina B1 , Inmunohistoquímica , Antígeno Ki-67/biosíntesis , Ganglios Linfáticos/metabolismo , Linfoma no Hodgkin/metabolismo , Tonsila Palatina/metabolismo , Valor Predictivo de las Pruebas , Pronóstico , Análisis de Supervivencia , Proteína p53 Supresora de Tumor/biosíntesisRESUMEN
Foram determinados os níveis amigdalianos de miocamicina em cinco pacientes após administraçäo de dose única de 10mg/kg e em 10 pacientes após dois dias de administraçäo de 10 mg/kg de 8/8 horas. No grupo de doses múltiplas, foram detectados níveis tissulares até 12 horas apús a administraçäo. Neste grupo, os valores observados (Cmax, AUC) foram superiores aos do grupo de dose única, apontando para um acúmulo tecidual do antibiótico com a repetiçäo das doses. Estas observaçöes reforçam a validade de um esquema de administraçäo da miocamicina de 12 em 12 horas