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Biomedical and Environmental Sciences ; (12): 19-28, 2021.
Artículo en Inglés | WPRIM | ID: wpr-878317

RESUMEN

Objective@#In the present study, the ABCA1 was used as a label to capture specific exosomes, the level of ABCA1-labeled exosomal microRNA-135a (miR-135a) was evaluated for the diagnosis of Alzheimer's disease (AD), especially in patients with early stages of AD.@*Methods@#This is a preliminary research focused on the levels of ABCA1 in WBCs, RBCs, HT-22 cells, and neuron cells. The diagnostic value of ABCA1-labeled exosomal miR-135a was examined using the CSF and serum of APP/PS1 double transgenic mice, and 152 patients with SCD, 131 patients with MCI, 198 patients with DAT, and 30 control subjects.@*Results@#The level of ABCA1 exosomes harvested from HT-22 cells and neuron culture medium was significantly higher compared to that of RBCs and WBCs ( @*Conclusion@#This study outlines a method to capture specific exosomes and detect them using immunological methods, which is more efficient for early diagnosis of AD.


Asunto(s)
Anciano , Anciano de 80 o más Años , Animales , Femenino , Humanos , Masculino , Transportador 1 de Casete de Unión a ATP/líquido cefalorraquídeo , Enfermedad de Alzheimer/líquido cefalorraquídeo , Biomarcadores/líquido cefalorraquídeo , Línea Celular , Disfunción Cognitiva/líquido cefalorraquídeo , Eritrocitos/metabolismo , Exosomas , Leucocitos/metabolismo , Ratones Transgénicos , MicroARNs/sangre , Neuronas/metabolismo
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