Acción del triclosan al 0.3 y cambios del pH salival en gestantes del departamento de ginecología y obstetricia del Hospital Daniel AlcidesCarrión, Lima-Perú / Effects of triclosan 0.3 and changes in saliva Ph during pregnancy at the ginecology and obstetrics department in Daniel Alcides Carrión Hospital in Lima-Perú

El objetivo del presente estudio fue demostrar la eficacia de un antimicrobiano de tipo fenol denominado Triclosan añadido a un dentífricosobre los cambios en el pH salival en gestantes del último trimestre. Se realizó un estudio clínico paralelo utilizando una muestra de 100 pacientes, aleatoriamente dividas en 2 grupos, 50 pacientes de experimentación quienes usaronun dentífrico conteniendo Triclosan al 0.3% y 50 pacientes control quienes usaron un dentífrico de uso común. Durante la investigación se registraron tres controles, un pH salival basal, un primer control inmediatamente despuésdel cepillado y un segundo control a las 5 horas post aplicación del dentífrico en ambos grupos durante tres días y luego se obtuvieron los promedios de cada paciente. Como resultado se halló una diferencia estadísticamente significativaentre los tres momentos de la evaluación, basal y luego de la aplicación de Triclosan al 0.3% adicionado a una pasta dental. Se registró una elevación importante en el pH seguida de un mecanismo de compensación que permitió la nivelación del pH hasta valores más elevados que los iniciales. Es decir permite una elevación temporal en el pH, luego la autorregulación bucal mantendría un medio adecuado alejado del denominado ôpH críticoõ que evitaría la instalación de la enfermedad cariosa.

The goal of this research was to determine the efficacy of the phenolic antibacterial Triclosan added toa toothpaste,in provide changes to thesaliva ph during the last trimester of pregnancyy. A parallel clinical study was made in 100 patients randomly divided into 2 groups, 50 using a dentifrice with Triclosan 0.3% and 50 controls using a standard tooth paste. During the studythree controls of the salival pH were registered, a baseline measurement, a first control right after brushing and finally 5 hours post application of the dentifrice. The measurements weremade in both groups during 3 consecutive days and the average were obtained from each patients. As a result, a statistically significant differencebetween the two groups (experimentation and placebo) during the three measurements, was demonstrated. Although the two groupsshowed a fall in the second measurement an important increase of the saliva pH was observed before using a dentifrice with Triclosan 0.3% following a compensatory mechanism keeping suitable saliva pH levels higher than the initial one. Therefore, Triclosan added to tooth pastes may help to raise the saliva pH levels when the oral environment reaches critical salivary pH levels.

Effects of a triclosan dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant women: five-month clinical results.

The objective of this study was to determine the effects of a triclosan/copolymer dentifrice on plaque formation, gingivitis and gingival bleeding in pregnant subjects. This double-blind clinical study was carried out in 180 women at 3 months of pregnancy. The subjects were stratified into two balanced groups according to their baseline plaque, gingivitis and bleeding scores. Subjects received a thorough dental prophylaxis and were assigned to brush with either a placebo or triclosan dentifrice for five months. They were instructed to brush their teeth as they normally would, twice a day for one minute per brushing. Follow-up examinations after five months of dentifrice use evaluated supragingival plaque, gingivitis and gingival bleeding. After five months, the triclosan dentifrice significantly reduced plaque formation, gingivitis and gingival bleeding by 40.5%, 22.5% and 35.3%, respectively, compared to the placebo group (p<0.05).

Comparative evaluation of efficacy of sodium fluoride, chlorhexidine and triclosan mouth rinses in reducing the mutans streptococci count in saliva : an in vivo study.

The primary objective of this study was to compare the efficacy of sodium fluoride (0.05%), chlorhexidine (0.12%) and triclosan (0.3%) mouth rinses in reducing the mutans streptococci count in saliva. 60 subjects in the age group of 12 to 14 years were selected from the schools of Mumbai and were equally divided into 4 groups. First 3 groups were test groups and the 4th group was control group. The subjects were instructed to rinse one full marked measure of mouth rinse for 1 minute, twice daily. Salivary samples were collected at baseline and after 2 weeks and cultured on M.S.B.agar. The number of mutans streptococci colonies were counted on agar medium. The results of the study confirmed that chlorhexidine mouth rinses are more efficient in reducing mutans streptococci count in saliva as compared to other mouth rinses.

Intracrevicular application of 0.3% Flurbiprofen gel and 0.3% Triclosan gel as anti inflammatory agent. A comparative clinical study.

This study compared the anti-inflammatory efficacy of Triclosan and Flurbiprofen in a gel form on clinical parameters of moderate gingivitis cases. The study comprised of 100 sites from 16 volunteers and used split mouth technique. 0.3% Triclosan/0.3% Flurbiprofen gels applied intracrevicularly once daily for one week. Clinical parameters like Plaque index, Gingival index and Bleeding index scores were recorded at 0 day, 4th day and 8th day. The obtained results showed significant reductions in clinical parameters from baseline to 8th day. This indicates local delivery of 0.3% Triclosan/0.3% Flurbiprofen gel can be used as an anti-inflammatory agents either alone or as an adjunct to scaling in periodontal therapy.