Study of thromboxane A2 in dysfunctional uterine bleeding

Thromboxane A2 [TXA2] level was determined in 25 cases with dysfunctional uterine bleeding [DUB] and in 10 cases with normal menstrual blood loss as control group. The patients were not taking anti prostaglandins or hormonal therapy during the last three months, the mean level of TXA2 in cases with DUB was 9.92 pg/0.1 ml plasma +/- 6.587, while in the control group the mean level of TXA2 was 26.7 pg/0.1 ml plasma at 9.03. The difference between the two groups was significant [P <0.001]. Thromboxane A2 being a potent vasconstrictor and a potent platelet aggregator is important in the control of bleeding from the uterus and its decrease level could be one of the etiological factors in the pathogenesis of DUB