Sulfato de vinblastina en el tratamiento del sarcoma de kaposi asociado al SIDA / Vinblastine in the treatment of kaposi sarcoma (KS) associated with AIDS

No se ha demostrado un impacto significativo en cuanto a medidas terapéuticas disponibles para el Sarcoma de Kaposi Epidémico. Sin Embargo, nosotros estudiamos el efecto anti-tumoral de la vinblastina en 6 pacientes con Sarcoma de Kaposi Epidémico. Nuestros resultados sugieren que la vinblastina como monoquimioterapia, puede ser útil en el tratamiento del Sarcoma de Kaposi Epidémico en aquellos pacientes con enfermedad localizada y con indicadores pronósticos favorables

Effect of methotrexate and vinblastine on odontogenesis in the rat

The effect of the antineoplastic agents methotrexate and vinblastine on odontogenesis of the continuously growing rat incisor has been investigated. Methotrexate resulted in marked degenerative changes of the odontoblasts and their replacement with large rounded cells having giant or double nuclei, these cells occupy the subodontoblastic zone. Ameloblasts expressed distal movement of their nuclei and signs of degeneration in more severly affected areas. Vinblastine resulted in hydropic degeneration, karyolysis and atrophy of the odontoblasts, fatty infiltration of the subodontoblastic cells, disorganization and degeneration of the ameloblasts. Both drugs resulted in marked decrease of staining reactivity of the odontoblasts and subodontoblastic cells to alkaline phosphatase. Tetracycline labelling revealed that treatment with methotrexate or vinblastine resulted in very highly significant decrease in dentin formed during the period of the experiment