Clinico-pathological findings of Clostridium perfringens type D enterotoxaemia in goats and its hemolytic activity in different erythrocytes

The present investigation was conducted to study the effects of experimental Clostridium perfringens type D enterotoxaemia in teddy goats. Clinical signs started to appear after 30 min of experimental infection like anorexia, diarrhea, dehydration, frothing and dyspnea. Gross lesions consisted of severe congestion in tissues of varying intensity with enlarged mesenteric lymph nodes while histological examination revealed edema of lungs, kidney, and lymph nodes and to some extent in brain along with hemorrhages in lungs and intestines. Clostridium perfringens type D carrying alpha and epsilon toxin genes were amplified with amplicon size about 247 bp and 665 bp, respectively. Human erythrocytes showed the highest hemolysis, 68%, followed by mice, 57%, against culture supernatants. The percentage of hemolysis was significantly higher at 37[degree]C as compared to 25[degree]C except for rabbit and dog

Unicystic ameloblastoma: a distinct clinicopathologic entity

Unicystic/ Cystic ameloblastoma [UCA] is a single cystic cavity which shows ameloblastomatous differentiation in the lining. First introduced in 1977, it contends on being a separate clinico pathological entity than the solid ameloblastoma. The clinical and radiographic features of UCA, its differential diagnosis, histopathology and current concepts of management have been discussed. This is a review article

ENT Mnifestations of wegener's granulomatosis

The purpose of this study was to find out the presenting features, diagnostic problems, treatment, and prognosis of Wegener's granulomatosis [WG], with special reference to ENT manifestations. It was a prospective descriptive study. The study was conducted at the Department of Otorhinolaryngology and Head and Neck surgery, Pakistan Institute of Medical Sciences [PIMS], Islamabad, from 1st March1999 to 30th Sep 2001. The ten patients included in this study comprised of six males and four females, with a male to female ratio of 1.5:1. The age of patients ranged from 16 years to 55 years with an average age of 38.5 years. The most common presentation in our patients was due to nasal involvement of disease. Nasal obstruction, epistaxis, and rhinorrhoea was seen in 80% of patients with WG. Next common symptom was headache [60%] followed by other symptoms Two patients had ear pain and conductive deafness along with nasal symptoms. One patient in addition to nasal symptoms mentioned presented with saddle nose deformity. One patient presented with hoarseness and progressive stridor, having subglottic stenosis as an isolated finding. Most common symptoms in WG localized to ENT region are nasal obstruction, rhinorrhoea and epistaxis. Biopsy and c-ANCA have key role in diagnosis of WG. ESR has a good prognostic relevance