Bleomycin Induced Pulmonary Fibrosis

Bleomycin is a widely used antineoplastic drug which produces dose and time-dependent interstitial pulmonary fibrosis in human and animals. The mechanism of bleomycin-induced lung injury is not well understood. However, current studies have shown that bleomycin can generate free oxygen radicals such as super -oxide and hydroxyl radical. In this study the antioxidant effect of vitamin C in biological system and its effect on bleomycin-induced lung fibrosis in rat has been investigated. In this study rats were divided into four groups: Control, bleomycin and Saline, bleomycin and vitamin C and saline and vitamin C. The degree of tissue injury in the bleomycin and vitamin C group was significantly lower than bleomycin and saline group. Results of this study suggest that vitamin C may reduce the fibrosis formation effect of belomycin in lung tissue

Study of anti-inflammatory and healing effects of achillea millefolium in the treatment of indomethacin-induced gasthic ulcer in rat

According to numerous sources, the plant "Achillea millefolium" is used for various ailments, mainly for disorders of the gastrointestinal tract or tonically for the healing of wounds. In this research, the effects of hydro-alcoholic extract [8:2V/V] of the plant Achillea millefolium on the treatment of gastric ulcer and possible hepatotoxicity of the plant in rat were studied. Hydro-alcoholic extraction of the plant was carried out using maceration, followed by concentrating under vacuum. Gastric ulcer in rat was induced by oral administration of indomethacin suspension [30mg/kg] in 1% carboxy methyl cellulose following 72 hours of fastin. Hydro-alcoholic extract of the plant was orally administrated as a single dose but in different concentrations of 125, 250, 500, 1000 and 1500 mg/kg for 14 days following induction of gastric ulcer in rats. At the end of the experimental period, animals were killed and the stomachs were examined both macroscopically and microscopically. All different concentration of Achillea millefolium were effective in treating of gastric ulcer specially those with concentrations of 500, 1000 and 1500 mg/kg which showed to be the most effective ones. The extract with concentration of 500 mg/kg was considered to be the most effective dose in treatment as no liver disorder was observed. Achillea millefolium is a suitable preparation in treatment of gastric ulcer