Normal bromsulfalein excretion in familial non-hemolytic jaundice

A patient with familial non-hemolytic jaundice with normal Bromsulfalein retention test is presented. Discussion on this unusual observation is done. It is suggested that preservation of BSP excretion by the liver cells occur inspite of defective excretion of bilirubin. It is postulated that this is due to the presence of binding site for the dye and not for bilirubin on the protein molecule carrier within the liver cytoplasm. The protein is necessary for excretion of substances by the liver. (Summary)