Résumé
Abnormal angiogenesis is reported in patients with con-heart diseases [CHD]. Angiogenic growth factors play an important role in the regulation of angiogenesis. This study was done to assess angiogenin [ANG] levels in children with CHD, its correlation with degree of hypoxaemia and its relation to the development of pulmonary hypertension [PH]. Serum ANG level was assessed by sandwich .enzyme immunoassay technique in 36 children with cyanotic congenital, heart diseases [CCHD] and in 35 children with acyanotic congenital heart diseases [ACHD]. Both groups were compared to 12 healthy controls of matched age and sex. CCHD patients had higher serum ANG levels compared to ACHD [177.8 +/- 53.7 Vs 149.4 . +/- 51.2 ng/ml, P=0.02] and controls m8 +/- 53.7 Vs 114.8 +/- 51.8 ng/ml, P 0.002]. A1VG was negatively correlated with pO2 and O2 saturation [r =-0.46, p=0.004 and r =-0.403, p 0.015; respectively]. AATG level in ACHD was not significantly different from controls [149.4 +/- 51.2 Vs 114.8 +/- 51.8 ng/ml, P=0.06]. In ACHD, patients with PH had significantly elevated ANG levels when compared to without PH [188.9 +/- 48,7 Vs 137.7 . +/- 46.6 ng/ml, P=0.011 and to controls [1 88.9 +/- 48.7 V 114.8 +/- 51.8 ng/ml, P=0.005]. Increased ANG in CCHD-secondary to hypoxemia-may responsible for abnormal angiogenesis in these patients. Increased ANG levels in ACHD patients with PH may be a compensatory mechanism aiming for neovasculrization distal to the site of pulmonary vascular obstruction