[Narcolepsia]

Narcolepsy is a chronic neurologic disease whose main features are excessive daytime sleepiness and cataplexy. It is a rare disorder which is most frequently sporadic. The age of onset shows two peaks. Both genetic and environmental factors play in its pathophysiolgy. Association with a specific HLA antigen and implication of the hypocretin system are very important findings. Narcolepsy's diagnosis is based on clinical findings but polysomnographic monitoring and multiple sleep latency test are usually necessary. Treatment of narcolepsy has been substantially modified with the advent of Modafinil which is effective as amphetamine with less undesirable effects. New etiologic treatments, such as hypocretin agonists, are currently being developed

[Toward optimization of small cell lung cancer management]

Small cell carcinoma represents 20 to 25% of all lung cancers. It is characterized by his quickly dissemination. Chemotherapy is the corner stone of small cell lung cancer therapy. However, therapeutic approach are depending on patient's performans states and the disease's extension

The role of radiotherapy is established in the treatment of limited disease. However irradiation's madilities are still discussed. Surgery, usually, contraindicated is, actually, possible in early stages [T1T2N0]. Recent advances in molecular biology have created new molecular targeted therapies for SCC but the benefits are not still evaluated. In this article, we review briefly classic strategies that have been evaluated in the management of patients with small cell carcinoma. This review will, also, focus in the main novel cytotoxic drugs and radiotherapy's modalities and for their clinical implication