Synthesis and reactions of 2, 9-Bis[4-N, N-dimethyl phenyl]- 5, 12-N, N'-Bis[aryl]-1, 5, 8, 12-tetraazatetracyclo-[6, 6, 0, 3, 70, 10, 140]tetradecane-4, 6, 11, 13-tetraones and their screening for biological activity.

Criss-cross cycloaddition reaction of aldazines 1 and 2 with N-arylmaleimides 3a-e represents an efficient method to obtain good yields of 2, 9-bis[aryl]-N, N'-5, 12-bis[aryl]-1, 5, 8, 12- tetraazatetracycl [6, 6, 0, 3, 70, 10, 140]tetradecane-4, 6, 11, 13-tetraones 4a-eand bromin-ated 5a-d, respectively, in solvent-free phase. Some of synthesized compounds were directed towards reduction, hydrolysis and dehydrogenation reactions to afford the expected compounds 6a-e, 7b, d, e and 8a, e respectively. The structure of the new synthesized compounds was confirmed spectrally [by IR, 1H NMR and Mass spectroscopy] and by elemental analysis. Some of the synthesized compounds were exhibit activity against some of bacterial and/ or fungal species.