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1.
Braz. j. med. biol. res ; 32(5): 529-38, May 1999.
Article Dans Anglais | LILACS | ID: lil-233471

Résumé

The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative amounts of its disaccharide units. Heparin, on the other hand, is present only in a few tissues and species of the animal kingdom and in the form of granules inside organelles in the cytoplasm of special cells. Thus, the distribution as well as the main structural features of the molecule, including its main disaccharide unit, have been maintained through evolution. These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. All indications obtained thus far suggest that these molecules perform the same functions in vertebrates and invertebrates


Sujets)
Animaux , Phénomènes physiologiques cellulaires , Héparine , Héparitine sulfate , Glycosaminoglycanes , Héparine/physiologie , Héparitine sulfate/biosynthèse , Héparitine sulfate/physiologie , Invertébrés , Mollusca , Vertébrés
2.
Braz. j. med. biol. res ; 27(9): 2097-102, Sept. 1994. ilus
Article Dans Anglais | LILACS | ID: lil-144462

Résumé

The sequence of the disacharide units of eight heparan sulfate proteoglycans of different origins is described. All heparan sulfates contain 5 variable regions made of oligosaccharide blocks of disaccharides, namely GlcUA(1-4) GlcNAc, GlcUA(1-4)GlcNS, IdoUA (104)GlcNS) and monosaccharides (GlcNS, and GlcNS,65) at the non-reducing terminal. The N-acetylated region of the heparan sulfates is linked to the serine of the protein core through a trisaccharide of Xyl-Gal-Gal. Heparan sulfates differ from one another in terms of the number of disaccharides that compose each block


Sujets)
Bovins , Chiens , Lapins , Animaux , Héparitine sulfate/composition chimique , Oligosaccharides/composition chimique , Protéoglycanes/composition chimique , Acétylation , Séquence glucidique , Fractionnement chimique , Diholoside/composition chimique , Données de séquences moléculaires , Polysaccharide-lyases/analyse , Analyse de séquence
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