Neonatal cardiac tamponade: what is the cause?

We present one case of neonatal cardiac tamponade due to percutaneous jugular venous catheterization, a rare and potentially fatal complication. In neonates with central venous catheters, the incidence of pericardial effusion [PCE] with tamponade is 0.5 - 2%. Perforation usually has a delayed course and results from endothelial injury, caused by the fluids, which leads to necrosis and thrombosis. This fluid then diffuses transmurally across the myocardium into the pericardium. Even if the catheter tip is placed properly and checked immediately after placement, it can migrate, an incidence which implies that the position of the catheter be checked at least twice a week after insertion

Cardiac tamponade and pericardial effusion due to percutaneous jugular venous catheterization

We present one case of neonatal cardiac tamponade due to percutaneous jugular venous catheterization, a rare, butpotentially fatal complication. In neonates with central venous catheters the incidence of pericardial effusion [PCE] with tamponade is 0.5-2%. Perforation usually has a delayed course and results from eridothelial injury, caused by the fluids, which leads to necrosis and thrombosis. This fluid then diffuses transmurally across the myocardium into the pericardium. Even if the catheter tip is placed properly and checked immediately after placement, it can migrate, an incidence which implicates that the position of the catheter should be checked at least twice a week after insertion

Relation of Xmn-1 Polymorphism & Five Common Indian Mutations of Thalassaemia with Phenotypic Presentation in b-Thalassaemia

Xmn-1 polymorphism is a known factor, which increases foetal haemoglobin production. Among, b thalassaemics in India five mutations are common. Disease severity was assessed based on age of presentation, age when received first transfusion and blood transfusion in ml/kg/year. Data was divided into three Xmn-1 categories, (+/+), (-/+), (-/-) and intergroup correlation was made. Mutations were divided into 2 groups, (group I) IVS 1-1 as one of its variables and (group II) without IVS 1-1. They were correlated. In Xmn-1 +/+ category 66.66% were diagnosed after one year of age, in mutations (group I) 53.57% had age of diagnosis after 1 year. 77.77% in Xmn-1 +/+ received their first blood transfusion after 1 year of age, in mutations (group I) 64.28% received their first blood transfusion after 1 year of age. About 66.66% patients in Xmn-1 +/+ category received blood <200ml/kg/year as against 72.22% in Xmn-1 -/- category. In mutations group I 57.14% received blood transfusion <200 ml/kg/year as against 68.18% in group II. It is concluded that the presence of Xmn-1 polymorphism and IVS 1-1 mutation leads to a milder phenotypic presentation causing a delay in onset of blood transfusions but dose not effect the amount of blood received /kg/year.