Comparative effects of metformin and pioglitazone on lipid profile of rabbits

This is the initial part of study in which the effects of two oral hypoglycemic drugs metformin and pioglitazone were studied on lipid profile of rabbits. White rabbits of both sexes were equally divided in to three groups each comprising of seven animals. Control group was given distilled water 2m1/kg, animals of group II were given metformin in the dose of 22mg/kg and animals of group III received pioglitazone in the dose of 0.5mg/kg. Serum concentration of cholesterol, very low-density lipoprotein [VLDL], triglycerides [TGs], low density lipoprotein [LDL] and high density lipoprotein [HDL] were measured after 8 week of oral dosing. Results shows that after 8 weeks animals received metformin did not reveal any significant change in lipid profile, but animals received pioglitazone showed significant [P<0.05] decrease in lipid profile, the decrease in cholesterol, LDL, VLDL and triglycerides is favorable however decrease in HDL is troublesome and warrant further investigations

Evaluation of hypolipidemic effect of citrus lemon

Herbs have been used for several cardio vascular diseases, such as congestive heart failure, hypertension, angina pectoris, atherosclerosis, arrhythmia, cerebral and venous insufficiency. Atherosclerosis is the primary cause of heart disease and stroke. Hence blood lipid levels are probably the major determinant of the development of cardiovascular disease. Citrus fruit and juices have long been considered a valuable part of a healthy and nutritious diet. It is well established that some of the nutrients in citrus promote health and provide protection against chronic disease. The present study has been specifically designed to investigate the hypolipidemic effects of citrus lemon juice in rabbits after high cholesterol diet for four weeks. The citrus lemon juice [1 ml/kg/day] revealed a significant reduction in serum cholesterol, triglycerides; low density lipoprotein levels and resulted in an increase in high density lipoprotein. These results suggest that the hypocholesterolemic effects of citrus lemon juice may be due to its antioxidant effect

Progression of chronic periodontitis in diabetic and non-diabetic subjects

A Cross-sectional study was carried out to compare the Progression of Chronic Periodontitis in Diabetic and Non-diabetic subjects. The study comprised of two groups of subjects having diabetics and non-diabetics respectively. The results showed a higher progression of Periodontitis in diabetic subjects with more pocket depth recession and loss of bone as compared to a non-diabetic subjects