Actividad inhibitoria y bactericida de cinco fluoroquinolonas sobre cepas multirresistentes de escherichia coli, acinetobacter baumanni y pseudomonas aeruginosa aisladas en hospitales de ciudades chilenas / Inhibitory and bactericidal activity of 5 fluoroquinolones over multiresistent strains of escherichia coli, acinetobacter baumanni and pseudomonas aeruginosa isolated in hospitals of chilean cities

Inhibitory and bactericidal activities of ciprofloxacin, temafloxacin, tosufloxacin, fleroxacin and E-4868 were determined against isolates of escherichia coli, acinetobacter baumannii and pseudomonas aeruginosa from varius chilean hospitals. Time-kill experiments were perfomed against one selected strain of these bacterial species. All quinolones showed high activity against E. coli as well as lower activity against P. aeruginosa and A. baumannii. Ciprofloxacin, temafloxacin, tosufloxacin, fleroxacin and E-4868 were rapidly bactericidal against E. coli, but only ciprofloxacin rapidly killed the strain of P. aeruginosa. E-4868 and tosufloxacin were also rapidly bactericidal against A. baumannii