Résumé
The oxidative stress causes biological damages in addition to the increase of cardiovascular system diseases such as angina pectoris. The present study aims to determine the oxidant and anti-oxidant [enzymatic and non-enzymatic] status in patients with angina pectoris. In this descriptive-analytical study, 24 hospitalized patients with angina pectoris and 63 healthy people, as control group, were selected. Blood fats including cholesterol, triglyceride and HDL were determined through the enzymatic method and the LDL was determined using Friedewald formula. The heparinized blood was used to measure superoxide dismutase, glutathione peroxidase [GPx], and plasma to determine malondialdehyde [MDA] and vitamin C through spectrophotometeric method and total antioxidant capacity [TAC] through ferric reducing ability of plasma [FRAP]. Vitamins A and E of serum were determined through the chromatography method in two groups and SPSS-11.5 software was used for statistical analysis. The degree of error in the tests was calculated as p<0.05. A significant difference was observed in blood fat contents as well as the oxidant and anti-oxidant [enzymatic and non-enzymatic] indices between the two groups [p<0.001]. A positive and significant relationship was observed between superoxide dismutase and vitamin C, MDA and LDL. However, this relationship with HDL and TAC was negative and significant [p<0.05]. With respect to the significant decrease of anti-oxidants and TAC and the increase of lipid peroxidation as well as the relationship between the different indices, the oxidative stress caused anti-oxidants system suppression in patients
Résumé
Permanent pacemakers provide effective relief of symptoms and are life-saving in patients with symptomatic heart block. Implantable cardioverter defibrillators [ICD] are also increasingly recognized as life-saving tools in various groups of patients with malignant ventricular tachyarrhythmias. As part of the "world survey on pacemaker and ICD implantations ", A survey of all device implantations in Iran during the year 2001 was performed. Data was collected and cross-checked through three sources i.e. direct contact with implanting physicians, pacemaker companies and the governmental pacemaker distributing body. During the year studied, 1635 patients received permanent pacemakers. 88% were new implants at an estimated rate of 24 per million population. The mean age of patients was 65 years and 56.2% were male. 40 cardiologists and 19 surgeons implanted the pacemakers at 27 centers throughout the country. Complete heart block was consistently the most common indication at all centers [mean 56.1%], sick sinus syndrome being the next most common one [mean 20.8%]. 69% of the pacemakers were single chamber pacemakers. Transvenous insertion of bipolar steroid-eluting passive fixation leads was the predominant practice at most centers. A total of 60 ICDs were implanted at 7 centers by 9 cardiologists. 45% of ICD implants were dual chamber devices. The survey is the only one available right now and provides useful information about the prevailing pacemaker and defibrillator implantation practice in Iran. Future surveys would be facilitated if a standardized implant registry such as that used in Europe were established in this country