RÉSUMÉ
Background: Adenoviral eye infection is contagious, self-limiting, causing symptoms like burning, pain, photophobia, and tearing. Diagnosis is clinical; existing treatments lack consistency. Ganciclovir, a selective and less toxic antiviral, shows promise for inhibiting viral DNA synthesis. The primary objective of this study was to assess the efficacy of topical 0.15% Ganciclovir gel in treating adenoviral keratoconjunctivitis, focusing on symptom and sign improvement during the follow-up period. Methods: A study at the National Institute of Ophthalmology and Hospital included 40 adenoviral keratoconjunctivitis patients diagnosed by cornea specialists. Symptoms were scored on a 0-3 scale during a 6-week follow-up. Patients were randomly assigned to group 1 (0.15% ganciclovir) or group 2 (artificial tear control). Data included history and ophthalmic exams. Statistical analyses used SPSS version 13.0 with p<0.05 significance, employing unpaired t-tests and chi-square tests. Results: A study with 40 adenoviral keratoconjunctivitis patients assessed Ganciclovir 0.15% ophthalmic gel efficacy. No age difference between groups was observed. Most patients were male (82.5%), spanning different economic classes. Symptom variations included more foreign body sensation in group 1 and increased watering in group 2. Group 1 exhibited faster symptom improvement over 6 weeks, while group 2 had a slower decline. Both groups experienced complications, but group 1 showed faster recovery, suggesting Ganciclovir's potential efficacy in treating adenoviral keratoconjunctivitis. Conclusions: In summary, the study confirms the effectiveness of 0.15% Ganciclovir gel in treating acute adenoviral keratoconjunctivitis, showing statistically significant and rapid improvement in signs and symptoms.
RÉSUMÉ
Background: Cardiovascular diseases are a leading cause of morbidity and mortality worldwide. The prevalence and risk factors of CVDs vary across different populations and regions. This study aimed to observe the cardiac profile among the adult population of Sreemangal, Bangladesh, to identify the prevalence and risk factors of CVDs in this population. Methods: This prospective observational study was conducted over a six-month period at a public health camp in Sreemangal, Bangladesh. A total of 137 adult participants were purposively selected. Data were collected through a structured questionnaire and physical examination, including measurements of blood pressure and laboratory analysis of blood samples. Results: The study found that 44.53% of participants had elevated blood pressure, and 21.90% had stage 1 hypertension. Interestingly, 36.50% of participants were unaware of their hypertension status. Furthermore, 26.28% of participants had a known history of diabetes, but blood glucose level analysis revealed an additional 14.85% of participants were prediabetic, and 6.93% were diabetic based on fasting blood glucose levels. A statistically significant association was found between increasing age and the stage of hypertension (p<0.001), and between fasting and normal blood glucose levels and the stage of hypertension (p<0.005 and p<0.05, respectively). Conclusions: The findings of this study underscore the need for targeted interventions to prevent and manage CVDs in the adult population of Sreemangal, Bangladesh. These interventions should include regular screening for CVD risk factors, health education to increase awareness of these risk factors, and strategies to promote healthy lifestyle behaviors.