Effect of glucosinolate autolysis products on rat serum T3 and T4 concentrations

The glucosinolate autolysis products of crushed seeds of Descurainia sophia L. [khakeshi] and Brassica napus L. [shelghem] were administered orally to rats in doses representing 8, 16 and 32gm seeds/kg body weight/day at intervals of 10,20 and sometimes 30 days. Serum T3 and T4 concentrations were reduced in 10 day-autolysate treated animals in a similar fashion to that found with methimazole. The antithyroid effect persisted until day 20, but was weaker than that seen with methimazole. By day 30, serum T3 and T4 concentrations returned to normal in plant treated animals