Résumé
The notification of intoxication is not compulsory in Brazil and this data is underestimated, although is recognizedly a public health problem. The objective of this article was to evaluate the intoxication case admitted to the hospitalar unity of regional reference, the Conjunto Hospitalar de Sorocaba (CHS). It was made a retrospective analysis of the datas (date, age, gender and toxic agent) obtained from bulletins of poisoned patients between september 2002 to septemmber 2003. Analysis was performed, initially, using a descriptive analysis following by Pearson Chi-Square and Fisher's Exact tests. There were 2,992 poisoning cases: the predominant age range was 36-50years: gender: male predominance (2,754 cases: 92%); toxic agent: abusive drugs (2,721 cases; 90.9%) with alcoholic predominance (2,383 cases; 87.6%), use of medicine together with dependence between toxic agent and gender (p<0.01), showing that abusive drugs are more used by men than women, whwreas the medicine are more used by womwn than men. The Fisher's Exact test, on the other hand, showed that the intoxication by abusive drugs occurs between 36-50 age range (p<0.01) and the medicine occurs between 21-35 years. We conclude that the psychoactive drugs are the responsible by the intoxication cases admitted to the CHS and we suggest the adoption of measures aiming to contain the intoxication cases mainly by alcohol and medicines...
Sujets)
Humains , Analyse de données , Intoxication/classification , Intoxication/diagnostic , Études rétrospectivesRésumé
OBJETIVO: Avaliar a presença de imunocomplexos e a atividade fagocitária de polimorfonucleares neutrofílicos em pacientes com Lúpus Eritematoso Sistêmico (LES) com e sem sinais e sintomas de atividade da doença. MÉTODOS: Analisou-se o sangue periférico de 55 indivíduos, sendo 10 pacientes com forma ativa da doença, 15 fora de atividade e 30 indivíduos sadios. Foi utilizada imunodifusäo radial para identificaçäo de imunocomplexos e estudada a etapa de ingestäo da fagocitose por neutrófilos com partículas de zimosan. RESULTADOS: Observou-se a presença de crioprecipitado constituído por IgM, IgG, IgA, componentes C3 e C4 do complemento nos pacientes com LES. As médias aritméticas da ingestäo por neutrófilos de partículas de zimosan incubado com soro homólogo e zimosan incubado com soro autólogo mostraram uma diminuiçäo significativa (p<0.05) para os pacientes com LES em atividade quando comparadas as de pacientes com LES fora atividade e de indivíduos sadios. CONCLUSÄO: Concluímos haver presença de imunocomplexos nos pacientes com LES em atividade e fora de atividade e uma diminuiçäo da fagocitose por neutrófilos no grupo de pacientes com LES em atividade. As conclusöes do presente estudo säo coerentes com a patogênese da doença e com a alta mortalidade por infecções nesses pacientes