Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Pakistan Journal of Medical Sciences. 2008; 24 (4): 512-516
Dans Anglais | IMEMR | ID: emr-89567

Résumé

Hyperprolactinaemia is a known cause of infertility. We explored the efficacy of carbegoline, the long acting dopamine agonist that was recently introduced into our medical practice. Seventy six patients with infertility secondary to hyperprolactinaemia were studied over a period of 20 weeks each. All the patients had carbegoline twice weekly for eight weeks. Two dosage regimen were used based on the pretreatment prolactin level; less than 50ng/ml had 0.25mg twice weekly [n=58] and 50ng/ml and above 0.5mg twice weekly [n=18]. Normalization of prolactin level was achieved in 75 [98.7%] patients. At the end of the study period, there was resumption of menstrual flow in 10 [76.9%] of the 13 patients that were amenorrhoiec and all the 39 [100%] patients that were oligomenorrhoeic had their normal menstrual cycle restored. Resumption of ovulatory cycles occurred in 87.7% of those with anovulatory cycles. Of the 76 patients, 69 [90.8%] got pregnant during the 20 weeks study. However, out of the 69 that got pregnant, 13 [18.8%] got pregnant while on carbegoline therapy. There was no case of carbegoline resistance or discontinuation recorded in this study. Carbegoline is a cost effective first line therapy in the management of infertile women with hyperprolactinaemia


Sujets)
Humains , Femelle , Hyperprolactinémie/complications , Infertilité féminine/classification , Infertilité féminine/traitement médicamenteux , Infertilité féminine/étiologie , Ergolines/analogues et dérivés , Ergolines/administration et posologie , Ergolines , Agents dopaminergiques , Prolactine/effets des médicaments et des substances chimiques , Prolactine/analyse , Prolactine , Aménorrhée/traitement médicamenteux , Aménorrhée/étiologie , Anovulation/traitement médicamenteux , Anovulation/étiologie , Oligoménorrhée/traitement médicamenteux , Oligoménorrhée/étiologie
SÉLECTION CITATIONS
Détails de la recherche