Résumé
Angiogenesis is increased in multiple myeloma [MM], Vascular endothelial growth factor [VEGF] is associated with progression of haematological malignancies and plays a role in increased angiogenesis seen in MM. CD117 [c-kit] is expressed in cells committed to myeloid lineage. Evaluation of the expression of CD 117 in bone marrow myeloma cells and its correlation with other laboratory data and the level of VEGF. Forty patients diagnosed as MM were included in this study. Ten healthy controls of matched age and sex. Patients and controls were subjected to complete blood picture, serum protein electrophoresis, serum level of beta 2 micro globulin and VEGF by Elisa technique. Study the expression of CD38/CD117 in double color by Facscalibur from BD company. In MM cases VEGF was significantly higher than normal controls. It was positively correlated with monoclonal protein and beta 2 microglobulin which is established to be a good prognostic indicator in MM. Co-expression of CD38/CD117 was higher in myeloma cells and showed a positive significant correlation with monoclonal protein, bone marrow myeloma cells, beta 2 microglobulin and VEGF level in serum. Study the co-expression of CD38/CD117and serum level of VEGF are beneficial in MM patients and can used as a good associated markers in MM. Also further studies on the role of c-kit in MM as a prognostic indicator would be of great benefit in raising the possibility of using tyrosine kinase inhibitors as a target therapy in MM patients