Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 40(2): 169-173, Apr.-June 2018. graf
Article Dans Anglais | LILACS | ID: biblio-959225

Résumé

Objective: N-acetylcysteine (NAC) is beneficial in psychiatric conditions, including schizophrenia. Patients with schizophrenia exhibit mesolimbic dopamine hyperfunction consequent to an endogenous sensitization process. This sensitization can be modeled in rodents by repeated exposure to psychostimulants, provoking an enduring amplified response at subsequent exposure. The aim of this study was to investigate the effects of NAC on amphetamine sensitization in mice. Methods: D-amphetamine was administered to C57BL/6 mice three times a week for 3 weeks; the dose was increased weekly from 1 to 3 mg/kg. NAC (60 mg/kg) or saline was administered intraperitoneally before saline or amphetamine during the second and third weeks. After a 4-week washout period, latent inhibition (LI) and the locomotor response to amphetamine 2 mg/kg were assessed. Results: Sensitization disrupted LI and amplified the locomotor response; NAC disrupted LI in control mice. In sensitized animals, NAC attenuated the enhanced locomotion but failed to prevent LI disruption. Conclusion: NAC warrants consideration as a candidate for early intervention in ultra-high risk subjects due to its safety profile and the relevance of its mechanism of action. Supplementing this proposition, we report that NAC attenuates sensitization-induced locomotor enhancement in mice. The finding that NAC disrupted LI incites a cautionary note and requires clarification.


Sujets)
Animaux , Mâle , Rats , Acétylcystéine/pharmacologie , Schizophrénie/traitement médicamenteux , Comportement animal/effets des médicaments et des substances chimiques , Stimulants du système nerveux central/pharmacologie , Activité motrice/effets des médicaments et des substances chimiques , Acétylcystéine/administration et posologie , Modèles animaux de maladie humaine , Amfétamine/administration et posologie , Stimulants du système nerveux central/administration et posologie , Souris de lignée C57BL
SÉLECTION CITATIONS
Détails de la recherche