Hyperbilirubinemia in preterm infants and neurodevelopmental outcome at 2 years of age

This survey generating the hypothesis that mild to moderate hyperbilirubinemia is causally related to impaired neurodevelopmental outcome. The data demonstrated that mild to moderate hyperbilirubinemia in preterm infants is associated with impaired neurodevelopmental outcome specially cerebral palsy. A linear increase of serum total bilirubin concentration will increase the risk of handicap in preterm infants. Increase of serum total bilirubin concentration in preterm infants will increase the risk of impaired cerebral electrical activity and change in electroencephalographic patterns