1.
Applications of RNA interference high-throughput screening technology in cancer biology and virology
Protein & Cell
;
(12): 805-815, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-757660
Résumé
RNA interference (RNAi) is an ancient intra-cellular mechanism that regulates gene expression and cell function. Large-scale gene silencing using RNAi high-throughput screening (HTS) has opened an exciting frontier to systematically study gene function in mammalian cells. This approach enables researchers to identify gene function in a given biological context and will provide considerable novel insight. Here, we review RNAi HTS strategies and applications using case studies in cancer biology and virology.