RÉSUMÉ
OBJECTIVE:To prepare film-coated Chenxianglubailu tablet and to improve its stability.METHODS:The core of the film-coated tablet was prepared with different cohesives;which were then coated with different coating substances.The stability of film-coated Chenxianglubailu tablet and that of the coated tablet were compared.RESULTS:The film-coated Chenxianglubailu tablet,with its tablet core made from10%polyvidone alcohol solution,which was protected by an insulation substance zein,which was prepared by gastric soluble yellow or marron coating power from Shanghai Colorcon Company was superior to other preparations made from other materials in appearance and quality,particularly in its oil-ooz?ing-proof and moisture-proof properties.The stability of film-coated tablet was superior to that of the sugar coated tablet.CONCLUSION:The film-coated Chenxianglubailu tablet is stable in quality and its preparation is simple.
RÉSUMÉ
Objective:To evaluate the therapeutic effects of compound naftifine cream on experimental dermatophytosis caused by trichophyton purpureatum or candida albicans.Methods:Two dermatophytosis models of 120 guinea pigs were made and divided into 6 groups( n =10) respectively.Topically 2.5%,1.25%,0.625% of compound naftifine cream and 0.5% cream ketoconazole and 2% cream naftifine and control agent were used in all laboratory animals respectively.All were used for 14days.Results:The efficacy of the compound naftifine cream in topically administered animals was better than that in the ketoconazole or nafiifine cream treatment groups ( P