Effect of D-400, a herbomineral preparation on lipid profile, glycated haemoglobin and glucose tolerance in streptozotocin induced diabetes in rats.

This study was undertaken to investigate D-400, a herbomineral formulation in streptozotocin induced diabetes in rats. Glycated haemoglobin, lipid profile and glucose tolerance test were studied. D-400 has an established hypoglycaemic effect in alloxan induced diabetes in rats as well as in non-insulin dependent diabetes mellitus patients. D-400 treated group showed lower glycated haemoglobin, triglycerides and higher HDL levels. The hyperglycaemic response was blunted after administration of oral glucose in the same group.

Effect of D-400, a herbal formulation, on blood sugar of normal and alloxan-induced diabetic rats.

Blood sugar levels of normal rats treated with D-400 showed significant reduction (P < 0.05) as compared to control groups. The fall was seen at one month and remained so uptill 3 months. Hyperglycemic response to adrenaline was significantly lowered (P < 0.05) following D-400 treatment. D-400 potentiated the hypoglycemia following tolbutamide treatment. Blood sugar remained persistently low in tolbutamide plus D-400 treated group after 3 and 4 hours (P < 0.05). In the alloxan-induced diabetic rats, a significant lowering of blood and urinary sugar was noticed on day 20, 30 and 40 following treatment with D-400 (P < 0.05). Liver glycogen depletion was significantly inhibited in the D-400 treated group (P < 0.025). D-400 has significantly potentiated (P < 0.05) the hypoglycemic action of insulin in alloxan-induced diabetic rats.