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Background: Pregnancy induced hypertension in women is a major cause of pregnancy related maternal, fetal, and neonatal morbidities and mortalities. Aim was to compare the clinical and hematological profile of newborns of mothers with and without pregnancy induced hypertension.Methods: This hospital-based case control study was conducted in Lala Lajpat Rai Hospital, Kanpur. Clinical and hematological profile of newborns of mothers with or without PIH were compared.Results: The low gestational age (35.44�89 weeks), low birth weight, thrombocytopenia (1.31�65 lakhs/mm3), absolute neutropenia (7.71�3�24�3cells/mm3) and deranged coagulation profile in newborns was found to have significant association with PIH in their mothers (p<0.05).Conclusions: This study concluded that newborns of hypertensive mothers carry a risk for prematurity, small for gestational age, infection and bleeding in early neonatal life.
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Objective: The objective of the study is to assess the knowledge regarding animal bite, prevention and control and study the association of the socio-demographic factors with knowledge regarding animal bite, prevention and control.Methods: An observational cross-sectional study was conducted in 280 animal bite victims attending animal bite OPD associated with Govt. Medical College Datia, Madhya Pradesh, India. Information collected with the semi-structured questionnaire after obtaining informed verbal consent for study duration of 3 mo. Data pertaining regarding knowledge of animal bite victims, prevention and control to the socio-demographic profile of victim, category of bite, age, sex, education, occupation, residence was collected. Data was analyzed using MS Excel and Epi Info software.Results: Among 280 victims 178(63.57%) were males, 156(55.7%) belongs to 15-45 y, 170(60.71%) were living in urban area, and 98(35%) and 89(31.7%) of the victims were agriculture worker and laborers respectively. 263(93.92%) victims bitten by dog of them 249(88.9%) by street dog, 221(78.92%) had Category III bite, lower extremity was affected in 280(75.71%), and 156(55.71%) of the victims were affected during evening hours.Conclusion: There is need for creating awareness in public and medical community about proper wound management and judicious use of anti-rabies vaccine.
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Background: This study aimed to find out the proportion of overweight and obese children of age 6-16 years having metabolic syndrome and to find out the risk factors for the same. Methods: This hospital based cross sectional study was conducted in obesity clinic of Department of Paediatric, Government T D Medical College, Alappuzha over a period of 18 months (from jan 2019 to june 2020). Sample size was calculated as 210 children including 20% expected dropout. Children of age 6-16 years with BMI > 85th centile attending the obesity clinics were enrolled for the study as per the inclusion and exclusion criteria. After getting consent/assent, relevant points from history, physical examination and investigations were recorded. The data obtained were entered in excel spread sheet and analyzed. Results: In this study, 28.9% were overweight and 71.1% were obese. Proportion of metabolic syndrome [MetS] among subject with overweight and obese were 18% and 29.3% respectively. Metabolic syndrome were more in males, children receiving more calories, have passive smoking and were born as preterm or big baby. Abdominal obesity was present in all children with MetS. Significant associations were found between MetS and inflammatory markers like CRP. Among the metabolic parameters, elevated level of uric acid, SGOT, SGPT and abnormal lipid profile were found to have a positive correlation with MetS. Conclusions: More than 25% of children with BMI > 85th centile is found to have MetS. Being overweight also is high risk for development of metabolic syndrome. High calorie intake, passive smoking, prematurity, birth weight more than 4 kg and abdominal obesity are significant risk factors identified.
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Dysmorphic head shape can be a presenting complaint of craniosynostosis which needs to be investigated in detail for any genetic or syndromic associations. Many genetic mutations have been associated with craniosynostosis but ERF gene mutation has been found to be very rare. Here, we have discussed about an 8 years old girl who presented with dysmorphic head shape. She had crouzoid features like exorbitism, malar hypoplasia with copper beaten skull appearance and pansynostosis on CT Head but genetic evaluation revealed ERF gene mutation suggestive of craniosynostosis 4. She had short stature which was the unique association with it. Thus, high index of suspicion should be kept for craniosynostosis 4 when phenotypic features are suggestive of crouzon syndrome as crouzon syndrome can phenotypically mimic craniosynostosis with ERF gene mutation and genetic analysis should be done to look for alternate cause of craniosynostosis; especially to look for ERF gene mutation.
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Background: Objective were to evaluate the efficacy of fractional CO2 laser in treating genito-urinary syndrome (GSM).Methods: We did a prospective observational study on 92 post-menopausal women aged 37-84 years during December 2022-December 2023 in a private clinic of district Kanpur. Fractional CO2 laser (Rosch, vaginal 3600 probe) in three sittings were done for women presenting with GSM at the interval of four weeks as a lunch break therapy. The outcome was studied in terms of visual analogue scale (VAS) having 0 to 10 rating at second, third and sixth months. The statistical analysis was performed using MS excel and GraphPad online statistical calculator.Results: Stress urinary incontinence, early prolapse, urinary incontinence was the commonest presenting complaints among females. Significant improvement was observed in VAS score in each follow up.Conclusions: The vaginal fractional CO2 laser can be used as an effective and safe treatment method in GSM. It is necessary to conduct studies with long-term follow-up.
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Ethmocephaly is a rare but lethal congenital anomaly. Its incidence rate is 1 in 15,000 live births and 1 in 250 in abortuses. Babies have typical dysmorphic facies in form of orbital hypotelorism, proboscis and low set malformed ears. 32 years old, daily wage labourer delivered a baby with ethmocephaly. Baby had typical facies, and no extracranial abnormality present. Baby was stillborn. She had no antenatal checkup or ultrasonogram done. However, she had history of ingestion of certain plants during early months of pregnancy. Ethmocephaly is a lethal anomaly and mostly eliminated prenatally. Although there is no diagnostic test for ethmocephaly, and confirmation of it is done only by appearance of baby after birth, important clues like recognition of risk factors like maternal diabetes, alcohol intake, ingestion of certain plants, antenatal hydrocephalus, should not be missed. Importance of routine antenatal checkup and ultrasonogram is emphasized. Recognition of risk factors and a possible co-relation with ingestion of certain other plants is also emphasized.
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Background: The current burden for recurrent pregnancy losses in India is quite high and is around 7.4% and majority of them with no definitive cause for pregnancy loss even after complete RPL workup. The objective of the study was to investigate the prevalence and possible association of chromosome polymorphisms with recurrent pregnancy loss patients.Methods: A single centre case-control retrospective study on RPL patients undergoing conventional cytogenetics culture techniques to rule out chromosome abnormalities.Results: The prevalence of chromosome polymorphism in the study was 33.7% (471/1400) high in comparison to previous studies. The acro ps+/- polymorphisms involving D/G group of chromosomes was significantly higher in the study group observed in 23.5% (330/1400) patients and 15.8% (58/366) in the control group p <0.005. The prevalence of 22ps+ subtype polymorphism was significantly higher in the patient groups with the odd ratio OR (95% CI)- 2.35 (1.245-4.434).Conclusions: This study substantiates the very high prevalence of CPMs and therefore should be interpreted cautiously till further strong evidence are available, until then patient should be counselled on case-to case basis. In future CPMs may play a crucial role in prognosis and management in unexplained RPL group with no other definitive cause identified after RPL workup as per recommendations from international and national guidelines.
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Radial head arthroplasty allows a high degree of customizability, and implant polarity has emerged as an important variable. The purpose of this meta-analysis was to evaluate differences in functional and clinical outcomes between patients receiving monopolar and bipolar radial head prosthetic implants. Methods: A systematic review and meta-analysis were employed, and 65 articles were identified in three databases. Twelve articles contained non-English or insufficient text and were consequently excluded, and 20 others did not contain sufficient data or follow-up. The remaining 33 articles were qualitatively and quantitatively reviewed. Results: In total, 33 populations were identified, with 809 unduplicated patients: 565 with monopolar and 244 with bipolar implants. In these respective patients, the mean follow-up was 40.2 and 56.9 months. Average Mayo Elbow Performance Score were 86.7 and 87.4 (P=0.80), respectively; average Disability of the Arm, Shoulder, and Hand scores were 17.9 and 14.7 (P=0.47), and average final flexion/extension arcs were 119.4° and 118.7° (P=0.48). Revision rates were 4.07% and 6.56%, while complication rates were 19.65% and 20.08% in the respective monopolar and bipolar patients. These increased relative risks associated with bipolar implants were not significant. Conclusions: Radial head implant polarity does not appear to affect functional outcomes. While bipolar prosthetic design may increase the risks of revision and complications, the increases were not significant. Level of evidence: IV.
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Background@#High blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the 27th and 28th day, ISO was administered to designate groups at the dose of 85 mg/kg s.c., to induce myocardial infarction. @*Results@#Free radical generation, including ROS, in diabetes following ISO administration, leads to the activation of both intrinsic and extrinsic pathways of apoptosis. Morin significantly (p ≤ 0.05) reduced oxidative stress (GSH, MDA, SOD), cardiac injury markers (CK-MB, LDH), inflammation (TNF, IL-6), and apoptosis (Bax, BCl 2 , Caspase-3). In addition, it also reduced insulin and blood glucose levels. Akt/eNOS, Nrf2/HO-1, MAPK signaling pathways, and Insulin signal transduction pathways were positively modulated by morin pre-treatment. @*Conclusions@#Morin attenuated oxidative stress and inflammation and also modified the activity of various molecular pathways to mitigate cardiomyocyte damage during ISO-induced MI in diabetic rats.
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Background: Congenital heart diseases are a major cause of mortality and morbidity in children. The aim of the study was to know the spectrum of congenital heart diseases in a tertiary care centre.Methods: This was a prospective, hospital based observational study done in Lala Lajpat Rai Hospital, Kanpur. Duration of study was 12 months. Patients with strong clinical suspicion of cardiac disease were enrolled and detailed clinical examination and laboratory findings of these cases were noted in a pre-structured proforma. The confirmation of presence of congenital heart disease was done by echocardiography.Results: 150 patients aged below 5 years presenting with signs and symptoms suggestive of CHD were evaluated in this study. 91 were found to have congenital heart disease. We found VSD in 31.87%, ASD in 29.98%, PDA in 9.9% TOF in 5.49% and complex heart diseases in 16.48% cases. When considering the age at presentation, we found maximum number of cases (46.15%) in 1 to 12 months of age, 37.37% cases in neonatal period, 16.48% cases in 1 to 5 years of age. Most common presenting complaint was difficulty in breathing, followed by feeding difficulty.Conclusions: Ventricular septal defect 31.87% was the commonest heart disease, followed by ASD 29.98%. The majority of these patients were seen in the age group 1 to 12 months of age.
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The principle that presents human activities and forms the basis of sustainable soil management must not negatively impact future generations. The soil can be degraded by human activity, natural events like erosion and other factors. Degraded or disturbed soil sometimes lacks organic matter when compared with neighbouring undisturbed areas. Organic amendments that are produced in huge quantity worldwide and have the potential to be widely used for soil reclamation include animal manure, biosolids, waste from fruit pulp, kitchen trash, paper mills, wood scraps, crop residues, etc. This review article explores the mechanisms through which organic addition alters physical, chemical and biological properties of the soil and defines significance of organic amendments in the soil reclamation, with a focus on amendment types and application rates for soil amelioration and biomass production. A large-scale use of organic amendments can speed up the initial reclamation process and produce self-sustaining net production. Though easily decomposable organic additions may have immediate but transient impacts, stable and less decomposable molecules may cause effects that last longer. Organic additions consisting of waste products from the forestry, urban and agricultural sectors are used to achieve land reclamation to attain mutual benefits.
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Allelopathy is a natural and eco-friendly process causes agricultural plants to generate phytotoxins called "allelochemicals" that hinder or promote growth. The chemical substances generated through allelopathy can be potential tool to control agricultural important pests. Allelopathy can replace agrochemicals for crop disease and pest management. Agrochemical used in agriculture pollute the environment, lowers food quality, and increases disease-resistant biotypes. An agronomist can collaborate with a molecular scientist or plant breeder to selectively boost disease suppression by understanding allelopathy's physiological foundation. Allelochemicals are natural pesticides that fight disease, weeds, and insects, according to experts. Disease management strategies have been redesigned recently. Frequently, structural modifications or the synthesis of chemical analogs increase their bioactivity. Even though the progress in this regard is sluggish, some encouraging results are emerging, and many more are anticipated in the near future. This review attempts to discuss these characteristics of allelopathy for the rational management of diseases.
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Plant growth regulators, also known as phytohormones, are a class of organic chemicals, either naturally occurring or artificially synthesised, that exert control over specific physiological processes in plants. The application of these substances elicits a range of effects on vegetables, encompassing seed germination, the disruption of seed dormancy, the commencement of flowering, the induction of gametocidal effects, the promotion of fruit set, the stimulation of parthenocarpy, and the facilitation of fruit ripening, among others. Auxin plays crucial factor in the development of several vegetable crops, including cucurbits. Notably, the application of Naphthalene acetic acid at a concentration of 10 ppm has been observed to exert a significant influence on sex expression, fruit set, and overall production in cucumber plants. The application of 4-CPA resulted in the greatest quantity of commercially viable fruit in tomato plants. The application of Naphthalene acetic acid at a concentration of 40 ppm exhibited the most substantial enhancements in leaf area, percentage of fruit set, total fruit production, as well as the quantity and weight of seeds per fruit in chilli plants. The treatment involving the application of 80 ppm Naphthalene acetic acid in brinjal resulted in the observation of increased fruit length, average weight of fruit per plant, and greatest fruit diameter. Gibberellin is also of significant importance, since it participates in using the gibberellic acid route to produce tomato plants that exhibit enhanced performance in both irrigated and water-limited environments, hence increasing their drought tolerance. The application of GA3 at a concentration of 75 ppm has been found to be highly beneficial in improving vegetative growth and yield characteristics in brinjal, as well as in several other vegetable crops as detailed in the present study. Additionally, they serve a crucial function in augmenting the output and productivity of many vegetables breeding programmes, and ensuring food safety.
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Fifteen genotypes of tomatoes (Solanum lycopersicum L.) with 18 yield contributing traits, were studied for correlations and path coefficients. The experiment has been done at Vegetable Research Farm of Department of Horticulture, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi-221005, during Rabi season of 2020-21. The experiment was laid under Randomized Block Design with three replications. Using genotypic correlation, it has been found that the fruit yield per plant significantly positively correlates with lycopene, titrable acidity, pericarp thickness, fruits per plant, ascorbic acid and days to 50% flowering. This indicates that the selection of these qualities will impact the number of fruits produced by each plant. Yield per plant was showed the significant positive direct effects with ascorbic acid, pericarp thickness, firmness, fruit yield per plant, TSS, locules per fruit, number of fruits per plant, fruit diameter, lycopene content, seed test weight and days to 50% flowering at the genotypic path coefficient level that indicated the selection for these traits might be effective and there is a possibility of improving yield per plant through selection based on these characters. The investigation contains the necessary information to support the objectives, as shown by the residual influence at the genotypic (0.198) and phenotypic (0.206) routes.
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Sodium hypochlorite (NaOCl) usage is increased extraordinarily after COVID-19. After lockdown, NaOCl is used as a disinfectant at every possible public and private place. Hospitals and Institutions were using it for the same purpose. In this study, NaOCl chemistry is investigated. Its impact on humans and the environment is also analyzed from the available literature. Although, some immediately recent research papers are also considered and mentioned in this paper. This paper also encapsulates information about NaOCl usage, advantage, comparison with other disinfectants, importance, precautions, etc. This study concludes the standardized use of NaOCland also recommends the policy required for its use.
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Background: Iron deficiency is the most common cause of anaemia worldwide. In-depth studies examining facilitators and barriers to oral iron therapy are lacking. The aim of our study is to determine the factors affecting the outcome of oral iron therapy in iron deficiency anaemia.Methods: This is an observational study conducted in a tertiary hospital in Mumbai in children in the age group of 12 to 60 months. Out of a total of 416 children screened, 208 were eligible for oral iron therapy and were given oral iron in the dose of 3 milligrams per kilogram per day and reviewed after two months. A comprehensive questionnaire was given to parents after the completion of therapy to study the factors affecting iron therapy. The details were then analysed using Excel sheets, and correlation was calculated using SPSS program version 20.0.Results: After 2 months of oral iron therapy, IDA was corrected in 68.98%. Factors that led to an unsatisfactory outcome with iron therapy were, history of low birth weight, past hospital admissions, gastrointestinal side effects, malnutrition, and children who had tea, milk, or food with iron therapy. In contrast, children who took iron on an empty stomach and along with vitamin C-rich foods had a significant increase in haemoglobin levels.Conclusions: Various modifiable factors affect adherence and outcome of oral iron therapy. Tea and Coffee are to be avoided when the child is on iron therapy. Meticulous counselling of parents and children is pivotal for the successful management of IDA with oral iron therapy.
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In the villages of Prathvipura, Karguwan, and PuraBadaura in the district of Jhansi, in the Bundelkhand region, the study was conducted by Rani Lakshmi Bai Central Agricultural University during the Kharif of 2021.Total ten front line demonstrations were conducted on Urd bean and Mung bean in 10 hectare area by the active participation of the farmers with the objective of improved technologies of Urd bean and Mung bean production potentials. The improved technology consisted of improved varieties viz. Virat (Mung bean) and IPU 2-43 (Urd bean), balanced fertilizers (based on soil testing) application and integrated weed, diseases and insect pests management, etc. Under FLDs of Urd bean and Mung bean, the average additional yield of the crops was obtained at 25kg/ha and 165kg/ha, while the increased yield over the local check was 23.86 % and 23.10% from respective varieties. The mean extension gap, technology gap, and technology index for Urd bean crop were recorded as 25kg/ha, 870kg/ha & 87.0% where, in the case of Mung bean, it was 165kg/ha, 357.5kg/ha, and 32.5%, respectively. Average and maximum net returns of Rs. 1890 & Rs. 21910.63 and the cost-benefit ratio were recorded as 0.30 and 1.56 from FLD of Urd bean and Mung bean, respectively, followed by local checks.
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Pneumonia is one of the most common respiratory disorder across the globe. Pneumonia is a leading cause of morbidity and mortality in children younger than the age of 5 years. Bronchopneumonia is one of the typically seen presentation of pneumonia occurring mainly in the pediatric population. If not treated promptly, it might become life-threatening. Since pneumonia is associated with significant morbidity and mortality, promptly diagnosing pneumonia, correctly recognizing any complications or underlying conditions, and appropriately treating patients are of prime importance. This case series aims at providing a discussion of the diagnosis, management and comprehensive plan of care for bronchopneumonia in pediatric population.
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Fast food consumption trend has become very popular worldwide. Globalization has led to rapid rise in the number of fast-food outlets in Asian countries. The present study focuses on reviewing the consumption pattern of fast food among young adults of South Asian and Southeast Asian countries. Here a shift has been witnessed from consumption of traditional homemade food which included healthy nutritious locally available foods toward fast foods and processed foods. An extensive review of existing scientific studies in several South Asian and Southeast Asian countries was carried out to analyse fast food consumption patterns of young adults. Globalization, affluence, busy schedules, increase in number of working female population, mass media, increase in fast food production and delivery outlets are some of the main reasons contributing to increasing fast food consumption trends. Several western fast-food franchises are now well established in developing Asian countries. Dining out culture has increased in the Asian society and is socially acceptable. A rapid nutritional shift in Southeast Asia may be due to increase in food availability and food purchasing power. Consumption of fast-food items is associated with increasing obesity rates among young adults. Such trends are also associated with the increasing prevalence of non-communicable diseases such as indigestion, hypertension, asthma, and other several diseases among South Asian and Southeast Asian adults.
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Purpose: To study the endoscopic ostium characteristics and outcome of 8 × 8 mm osteotomy in external dacryocystorhinostomy (DCR) using the microdrill system. Methods: This prospective interventional pilot study was performed on 40 eyes of 40 patients with primary acquired nasolacrimal duct obstruction (NLDO) from June 2021 to September 2021 in patients undergoing external DCR. An 8 × 8 mm osteotomy was performed using round, cutting burr attached to a microdrill system. Success was defined as patent ostium on lacrimal syringing (anatomical) and a Munk score <3 (functional) at 12 months. Postoperative endoscopic ostium evaluation was done using a modified DCR ostium (DOS) scoring system at 12 months. Results: The mean age of the study participants was 42.41 ± 11.77 years and the male?to?female ratio was 1:4. The mean duration of surgery was 34.15 ± 1.66 minutes and that for osteotomy creation was 2.5 ± 0.69 minutes. The mean intraoperative blood loss was 83.37 ± 11.89 ml. Anatomical and functional success rates were 95% and 85%, respectively. The mean modified DOS score was “excellent” in 34 patients (85%), “good” in 1 patient (2.5%), “fair” in 4 patients (10%), and “poor” in 1 patient (2.5%). Complications included nasal mucosal injury in 10% (4/40) of patients, complete cicatricial closure of ostium in 2.5% (1/40), incomplete cicatricial closure in 10% (4/40), nasal synechiae in 5% (2/40), and canalicular stenosis in 2.5% (1/40). Conclusion: An 8 × 8 mm–sized osteotomy created by powered drill and covered by lacrimal sac–nasal mucosal flap anastomosis in external DCR is an effective technique that has minimal complications and shorter surgical time