Résumé
Nausea and vomiting of moderate intensity are especially common complaints from early pregnancy until approximately 12 weeks. It occurs in almost 50% of pregnancies and is associated with younger age, heavier maternal weight, primigravidas and a history of previous emesis if multiparous [Wlebanoff et al., 1985]. Hyperemesis gradvidarum is the most severe form of this disorder occurring in 1-2% of pregnancies and is accompanied by weight loss, ketonemia, electrolyte imbalance and profound volume depletion [Leylek et al, 1996]. Heficobatcter pylorus has been associated as a causative agent in the development of chronic antral gastritis [Dixon 1989] and seems to be an important factor in duodenal ulcer recurrence [Tytgat et al 1990]. Aim of the Work: The aim of the work is to investigate the hypothesis that there is an association between hyperemesis gravidarum [HG] and helicobatcter pylori [HP] infection. Patients and The study group consisted of 65 pregnant women with hyperemesis gravidarum who were admitted to Kasr El-Eini and El- Menofiya University Hospitals, from January 1999 to May 2000. The control group was 65 pregnant women attending Kasr El-Eini, and El-Menofiya University outpatient clinics. Helicobacter pylori serum immunoglobulin [IgG] was measured and compared between both groups. The prevalence of HP infection was highly significantly increased in the HG group than in the control group [90.8% [59 cases] versus 53.8% [35 cases] P < 0.001]. The antibody index was highly significantly increased in the HG group than in the control group [1.97 +/- 0.21] versus [1.31 +/- 0.14] P < 0.001. HP infection seemed to be significantly associated with hyperemesis gradvidarum in our pregnant population