Résumé
One of the factors affecting the compliance in chemotherapy i duration of therapy. It is sseen in treatment of malaria with quinine in which its long course and side effects limit the patient's compliance. In this study two different short courses of artemether mefloquine were deployed. 27 patients in Group 1 received oral artemether 320 mg stat dose followed by mefloquine 750 mg after 24hours. In Group 2,28 patietns received same dose of Artemether followed by mefloquine 750 mg and 500 mg after 24 and 30 hours. Short parasite clearance times were observed a 28.74 + or - 15.16 hours in Group land 35.82 + or - 23.62 hours in Group 2. The cure rates were 74.07 per cent in firt group and 92.86 per cent in the latter. (p=0.06.Firsher xact test) The short course brought no side effects.
Sujets)
Paludisme à Plasmodium falciparum , Méfloquine , Antipaludiques , MyanmarRésumé
One of the factors affecting the compliance in chemotherapy is duration of therapy. It is seen in treatment of malaria with quinine in which its long course and side effects limit the patient's compliance. In this study two different short courses of artemether mefloquine were deployed. 27 patients in Group 1 received oral artemether 320 mg stat dose followed by mefloquine 750 mg after 24 hours. In Group 2, 28 patients received same dose of Artemether followed bymefloquine 750 mg and 500 mg after 24 and 30 hours. Short parasite clearance times were observed as 28.74 + or - 15.16 hours in Group 1 and 35.82 + or - 23.62 hours in Group 2. The cure rates were 74.07
in first group and 92.86
in the latter. (P=0.06. Firsher exact test) The short course brought no side effects.
Sujets)
Méfloquine , Paludisme à Plasmodium falciparumRésumé
Dihydroartemisinin, one of the artemisinin derivativesis getting into frequent use for its lower price and higher efficacy. In this study 32 and 21 patients eith uncomplicated falciparum malaria were treated with dihydroartemisinin tablet produced as Cotecxin, 480 mg over 3 days and 480 mg over 7 days respectively. The initial cure rates in both treatment groups were 100 per cent but 34.37 per cent recurred in 3 day treatment group and 19.05 per cent in 7 day treatment. The resistance was only at R1 level and the recrudescence rates in both groups were not significantly different (P=0.37). The parasite clearance times PCTs ere 29.1 + or - 1hours in 3 day treatment and 26.62 + or - 12.77 hours in 7 day treatment. All patients in both groups ere free of side effects. The results support the previous findings that shorter course of artemisinin derivatives bring higher recrudescence.
Sujets)
Paludisme à Plasmodium falciparum , Antipaludiques , MyanmarRésumé
To find out whether the combination regimen of mefloquine and artesunate tablets improves the cure rate in uncomplicated falciparum malaria compared to the use of mefloquine and artesunate as single agents, a prospective, randomised, uniblind controlled study was done between May and November 1991, on one hundred and eighty cases of acute uncomplicated falciparum malaria. The patients were randomised to the following three frug regimens: - (1) Mefloquine - 1000 mg stat, (2) Tab Artesunate 600 mg over 48 hours, (3) Mefloquine 1000 mg plus tab Artesunate 600 mg over 48 hours. The regimen of mefloquine as a single agent gave a cure rate of 83.3 percent (with R1 = 15 percent and R2 = 1.7 percent), PCT = 52.15 + 55.2 hours and FCT = 23.98 + 59.87 hours. Tab artesunate gave a cure rate of 75 percent (with R1 = 25 percent), PCT = 33.16 + 5.15 and FCT = 23.4 + 22.7 hours. The combination regimen gave a cure rate of 98.27 percent with only one patient recrudescing at R1 level, PCT = 35.11 + 29.16 and FCT = 8.15 + 10.34 hours. The side effects were not much increased by using the combination. No cardiovascular effects were noted. The combination is superior to that of the single agents.