Effect of some drugs with immunosuppressive properties on IgE mediated mast cell degranulation and delayed type hypersensitivity

This study was carried out on 60 adult albino rats and 30 mice of cyclosporin A [CsA], methotrexate [MTX], ribavirin and dexamethasone [Dxt] on peritoneal mast cell [PMC] histamine release, passive cutaneous anaphylaxis [PCA] reactions in rats and DTH in mice. The studied animals were divided into three groups: The first was to study the effect of previous drugs on PMC histamine release in actively sensitized rats, the second was to study the effect of previous drugs on PCA in passively sensitized rats and the third was to study the effect of previous drugs on the induction of DTH in mice in vivo. Each group was divided into five subgroups and were pretreated with saline [control] or one of the previously mentioned drugs