Résumé
Introduction: Beta-thalessemia is a chronic disease that can cause psychosocial problems in patients and their sibling. The purpose of this study was to determine psychosocial problems of thalassemic children and their sibling and compare them with control group
Methods: This is a discriptive commparative study that conducted by structrual interview and PSC check list. The sample size was 572 children that 167 of them were thalassemic children between 4 to 16 years Old, and 166 of their sibling without chronic diseases in same age group and 239 of healthy children in similar age as compare group. The collected data were analysized with descreptive and analytic Ststistics by X[2], ANOVA and t-test
Results: Among all children, 20.4% of thalassemic, 12% of their healthy sibling and 7.9% of healthy children had psychosocial problems and these difference were significant
Conclusion: Whether thalassemic children have psychosocial problems their sibling who live with them have more psychosocial problems than healthy children So due to this finding it is better in care plans to pay special attention to the sibling of thalesmic patients
Résumé
Considering the antioxidant properties of Otostegia persica extract and role played by antioxidant agents in the improvement of diabetes mellitus, this study investigated the effect of its methanolic extract on serum levels of glucose and lipids in type I diabetic male rats. Type I diabetes was induced in male Wistar rats by injection of 70 mg/kg, i.p of streptozotocin. Before and 5 days after injection, fasting blood samples were collected for measurement of glucose and lipids serum levels. Diabetes was confirmed in rats having FBS above 250 mg/dl. Diabetic rats were divided to 15 groups receiving 100, 200 and 300 mg/kg extract, glibenclamide [600 micro g/kg] and distilled water [0.5 ml] daily for 3, 6 and 14 days, individually by gavage. Fasting blood samples were collected at the specified time points and serum levels of glucose, cholesterol and triglycerides were measured, using commercial kits by spectrophotometery. Treatment of diabetic rats with O.persica extract [100, 200 and 300 mg/kg] for 6 and 14 days and at 300 mg/kg for 3 days significantly decreased glucose serum levels. Also extract at different doses for 3, 6 and 14 days significantly decreased cholesterol and triglycerides serum levels. Extract was more effective than glibenclamide in reducing glucose and triglycerides serum levels in diabetes. Otostegia persica extract has antihyperglycemic and antihyperlipidemic properties in diabetic rats