Coronary artery disease risk factors in an urban and peri-urban setting, Kerman, Southeastern Iran [KERCADR study]: methodology and preliminary report

This article was to present the sampling and measurements methods and the main preliminary findings of the KERCADR cohort study [first round] in an urban and peri-urban setting, Kerman, southeastern Iran2009-11. 5900 [3238 female] people aged between 15 to 75 years were recruited in the household survey by non-proportional to size one-stage cluster sampling. Trained internal specialists, general practitioners, clinical psychologists and dentists have assessed the study subjects by person-assisted questionnaires regarding different NCD risk factors including cigarette and opium smoking, physical activity, nutrition habits, anxiety, depression, obesity, hypertension and oral health. Blood samples were also collected for determining FBS, HbA1c, cholesterol and triglyceride. Weighted standardized prevalence estimates were calculated by STATA 10 survey analysis package. The participation rate was more than 95% in all subgroups. Cigarette smoking [18.4% vs. 1.2%], opium use [17.8% vs. 3.0%] and triglyceridemia [16.1% vs. 12.0%] were significantly higher among men than women. In contrast, women were presented with higher level of sever anxiety [29.1% vs. 16.7%], obesity [16.8% vs. 9.2%], low-physical activity [45.1% vs. 39.2%] and uncontrolled diabetes [60.2% vs. 31.0%]. More than 68% of all subjects have presented with moderate to severe gingival index scores. The first round of the KERCADR cohort with sufficient sample size and response rate provided precise estimates for the main clinical and para-clinical NCD risk factors. These evidences need to be translated into public health interventions and monitored in the next rounds of the cohort

[Safety, efficacy and clinical outcome of direct stent implantation]

Conventional methods of stenting require predilatation, which potentially increase vessel wall injury and cost of the procedure. In this study, the safety and efficacy of direct AVE-S7 [Medtronic-USA] stent placement were evaluated in 100 patients. Quantitative coronary angiography was performed at the baseline and post-stent. Clinical follow-up was done up to 9 months. In 100 patients [76 male/24 female; mean age 51+/-12 years], with stable angina [n=84; 84%] and unstable angina [n=16; 16%], 102 AVE-S7 stents [diameter 3.2 +/- 0.2 mm] were implanted for 102 stenoses. Direct stenting was successful in all stenoses. No stent was lost or damaged and all stents were implanted at the target site. Angiographic success [<30%residual stenosis] was achieved in all lesions. In the 9-month follow up, none of the patients died. Target lesion revascularization became necessary in 8 [8%] patients after 3 months and in 4 [4%] other patients after 6 months. After 6 months, 78patients [78%] and after 9 months 82patients [82%] were free of anginal symptoms and after 9 months 80% of the patients were free of the ischemic events. This study demonstrates the safety and efficacy of direct placement of the AVE-S7 stent as well as its favorable clinical and angiographic results up to the 9 months after the procedure