1.
Indian J Exp Biol
;
1992 Jul; 30(7): 611-4
Article
Dans Anglais
| IMSEAR
| ID: sea-57508
Résumé
Animals pretreated with cromakalim (1 mg/kg,po) along with isoproterenol (85 mg/kg,sc) showed less myocardial degenerative changes on histopathological examinations when compared with those treated with isoproterenol alone. Cromakalim's beneficial effects on myocardium were in dose-dependent manner. Administration of cromakalim (po) lowered significantly the serum LDH and SGOT and depleted intracytoplasmic glycogen as demonstrated by periodic schiff staining procedure. Increase in blood clotting time was highly significant (P less than 0.001). The results suggest cardioprotective effect of cromakalim in isoproterenol induced myocardial infarction.
Sujets)
Animaux , Aspartate aminotransferases/effets des médicaments et des substances chimiques , Benzopyranes/pharmacologie , Coagulation sanguine/effets des médicaments et des substances chimiques , Cromakalim , Femelle , Glycogène/métabolisme , Isoprénaline , L-Lactate dehydrogenase/sang , Numération des leucocytes/effets des médicaments et des substances chimiques , Mâle , Infarctus du myocarde/induit chimiquement , Myocarde/anatomopathologie , Pyrroles/pharmacologie , Rats , Vasodilatateurs/pharmacologie , Vérapamil/pharmacologie
2.
Article
Dans Anglais
| IMSEAR
| ID: sea-18081
3.
Article
Dans Anglais
| IMSEAR
| ID: sea-19851
4.
Article
Dans Anglais
| IMSEAR
| ID: sea-24184
5.
Article
Dans Anglais
| IMSEAR
| ID: sea-23225