The predictive effect of TyG index on type 2 diabetes mellitus / 中华内分泌代谢杂志

Objective:To investigate the predictive effects of triglyceride-glucose index(TyG) 0 h, TyG 1 h, and TyG 2 h on type 2 diabetes mellitus(T2DM) in elderly male participants without diabetes.Methods:A total of 862 subjects were selected and followed up for 20 years, retrospectively. At baseline, all subjects underwent 75 g oral glucose tolerance test(OGTT) and venous plasma glucose measurements were taken before OGTT(FPG), 1 h and 2 h after OGTT(1 h-PG and 2 h-PG, respectively). Fasting blood lipids and other important biochemical indicators were also detected. The index of fasting serum triglycerides(TG) and FPG, 1 h-PG, 2 h-PG were TyG 0 h, TyG 1 h, TyG 2 h, respectively. Cox proportional hazards regression model and receiver operating characteristic(ROC) curve were used to evaluate the predictive effect of TyG 0 h, TyG 1 h, and TyG 2 h on T2DM.Results:The results of Cox regression model indicated that TyG 0 h, TyG 1 h and TyG 2 h had predictive effects on T2DM at 10 and 20 years of follow-up [At 10 years of follow-up, TyG 0 h: HR=1.538(95% CI 1.267-1.868), P<0.001; TyG 1 h: HR=2.224(95% CI 1.852-2.672), P<0.001; TyG 2 h: HR=2.117(95% CI 1.777-2.522), P<0.001; and after follow-up for 20 years, TyG 0 h: HR=1.431(95% CI 1.204-1.700), P<0.001; TyG 1 h: HR=2.008(95% CI 1.705-2.364), P<0.001; TyG 2 h: HR=1.850(95% CI 1.582-2.163), P<0.001]. After 10 years of follow-up, the area under the curve(AUC) of TyG 0 h, TyG 1 h, and TyG 2 h for predicting T2DM was 0.699, 0.747, and 0.739, respectively. Comparison of AUC, TyG 1 h or TyG 2 h>TyG 0 h. After 20 years of follow-up, AUC of TyG 0 h, TyG 1 h, and TyG 2 h for predicting T2DM was 0.671, 0.723, and 0.705, respectively. Comparison of AUC, TyG 1 h>TyG 2 h>TyG 0 h. Conclusion:The predictive role of TyG 1 h and TyG 2 h in T2DM is superior to TyG 0 h, and TyG 1 h′s long-term predictive effect on T2DM is better than TyG 2 h, which can be used as a reference index to evaluate the risk of T2DM in clinical practice.

A survey of correlation between serum 25-hydroxyvitamin D levels and dyslipidemia rlsk among middle-aged individuals in Beijing / 中华内科杂志

Objective To evaluate vitamin D status in middle-aged subjects in Beijing and explore the correlation between serum 25-hydroxyvitamin D[25(OH)D] levels and dyslipidemia.Methods A total of 448 individuals over 40 years old were enrolled in the cross-sectional survey.The general information,blood biochemical and lipid profiles and serum 25 (OH) D levels were collected.The subjects were either divided into two groups (the dyslipidemia group and the non-dyslipidemia group) based on the lipid levels,or four groups according to quartiles of 25 (OH) D levels.The association between 25 (OH) D levels and dyslipidemia risk was analyzed by a logistic regression analysis.Results A total of 234 cases were in dyslipidemia group,which accounted for 52.23％ of the subjects.The serum 25 (OH) D levels were significantly lower in the dyslipidemia group than in the non-dyslipidemia group both in men and in women (all P ＜ 0.05).The median serum 25 (OH) D level in the total subjects was 15.7 (12.2,20.1) μg/L with 91.1％ subjects of serum 25 (OH) D level ＜ 30 μg/L.The proportion of subjects with dyslipidemia (high TC,high TG,high LDL-C,or low HDL-C) increased with the decrease of 25 (OH) D level quartiles (P ＜0.05).After adjustment of confounding factors,the logistic regression analysis showed that subjects in the lowest 25 (OH) D quartile group had 143％ higher risks for dyslipidemia than those in the highest quartile group.Conclusion These findings indicate that 25 (OH) D insufficiency is highly prevalent among middleaged individuals and it may be associated with the risk of dyslipidemia.