Résumé
Objective: To explore the clinical diagnosis and treatment of huge thrombus in ascending aorta, and to clarify its treatment methods. Methods: The clinical materials of one patient with ascending aortic thrombus were retrospectively analyzed and the diagnosis and treatment were summerized, and the relevent literatures were reviewed. Results: The patient was male, and admitted to hospital due to space-occupying lesion in the ascending aorta in routine examination. The results of aortic CTA reported that there was a 22 mm×22 mm×45 mm spaceoccupying lesion in the ascending aorta. The patient was successfully treated with thrombectomy and ascending aorta replacement in order to prevent the systemic embolization. The histopathological examination revealed that the lesion was thrombus. Conclusion: Aortic CTA is a useful examination for the patients with thrombus in ascending aorta. Resection of thrombus and implantation of vascular graft can reduce the risk of recurrent stroke effectively.
Résumé
Objective To design and synthesis novel triazole antifungal derivatives with dithiocarbamates side chain and study the antifungal activities .Methods Nine title compounds were synthesized and characterized by 1 H NMR ,MS spectra . The in vitro antifungal activities of all the compounds were evaluated against eight human pathogenic fungi .Results The title compounds exhibited strong antifungal activities .Some compounds showed excellent activities against Candida albicans with the MIC80 values less than 0 .125 g/ml ,6d was 64 times higher than that of Itraconazole .Conclusion The introduction of the propyl ,sulphur and benzyl moiety to the side chain could affect the antifungal activities .