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1.
Braz. j. med. biol. res ; 49(5): e5244, 2016. tab, graf
Article Dans Anglais | LILACS | ID: biblio-951679

Résumé

Levamisole has been increasingly used as an adulterant of cocaine in recent years, emerging as a public health challenge worldwide. Levamisole-associated toxicity manifests clinically as a systemic vasculitis, consisting of cutaneous, hematological, and renal lesions, among others. Purpura retiform, cutaneous necrosis, intravascular thrombosis, neutropenia, and less commonly crescentic nephritis have been described in association with anti-neutrophil cytoplasmic antibodies (ANCAs) and other autoantibodies. Here we report the case of a 49-year-old male who was a chronic cocaine user, and who presented spontaneous weight loss, arthralgia, and 3 weeks before admission purpuric skin lesions in the earlobes and in the anterior thighs. His laboratory tests on admission showed serum creatinine of 4.56 mg/dL, white blood count 3,800/μL, hemoglobin 7.3 g/dL, urinalysis with 51 white blood cells/μL and 960 red blood cells/μL, and urine protein-to-creatinine ratio 1.20. Serum ANCA testing was positive (>1:320), as well as serum anti-myeloperoxidase and anti-proteinase 3 antibodies. Urine toxicology screen was positive for cocaine and levamisole, with 62.8% of cocaine, 32.2% of levamisole, and 5% of an unidentified substance. Skin and renal biopsies were diagnostic for leukocytoclastic vasculitis and pauci-immune crescentic glomerulonephritis, respectively. The patient showed a good clinical response to cocaine abstinence, and use of corticosteroids and intravenous cyclophosphamide. Last serum creatinine was 1.97 mg/dL, white blood cell count 7,420/μL, and hemoglobin level 10.8 g/dL. In levamisole-induced systemic vasculitis, the early institution of cocaine abstinence, concomitant with the use of immunosuppressive drugs in severe cases, may prevent permanent end organ damage and associate with better clinical outcomes.


Sujets)
Humains , Mâle , Adulte d'âge moyen , Purpura/induit chimiquement , Lévamisole/effets indésirables , Cocaïne/effets indésirables , Vascularite systémique/induit chimiquement , Glomérulonéphrite/induit chimiquement , Purpura/anatomopathologie , Vascularite systémique/anatomopathologie , Glomérulonéphrite/anatomopathologie
2.
Braz. j. med. biol. res ; 49(4): e5176, 2016. tab, graf
Article Dans Anglais | LILACS | ID: biblio-951666

Résumé

HIV infection has a broad spectrum of renal manifestations. This study examined the clinical and histological manifestations of HIV-associated renal disease, and predictors of renal outcomes. Sixty-one (64% male, mean age 45 years) HIV patients were retrospectively evaluated. Clinical presentation and renal histopathology were assessed, as well as CD4 T-cell count and viral load. The predictive value of histological lesion, baseline CD4 cell count and viral load for end-stage renal disease (ESRD) or death were determined using the Cox regression model. The outcomes of chronic kidney disease (CKD) and ESRD or death were evaluated by baseline CD4 cell count. The percent distribution at initial clinical presentation was non-nephrotic proteinuria (54%), acute kidney injury (28%), nephrotic syndrome (23%), and chronic kidney disease (22%). Focal segmental glomerulosclerosis (28%), mainly the collapsing form (HIVAN), acute interstitial nephritis (AIN) (26%), and immune complex-mediated glomerulonephritis (ICGN) (25%) were the predominant renal histology. Baseline CD4 cell count ≥200 cells/mm3 was a protective factor against CKD (hazard ratio=0.997; 95%CI=0.994-0.999; P=0.012). At last follow-up, 64% of patients with baseline CD4 ≥200 cells/mm3 had eGFR >60 mL·min-1·(1.73 m2)-1 compared to the other 35% of patients who presented with CD4 <200 cells/mm3 (log rank=9.043, P=0.003). In conclusion, the main histological lesion of HIV-associated renal disease was HIVAN, followed by AIN and ICGN. These findings reinforce the need to biopsy HIV patients with kidney impairment and/or proteinuria. Baseline CD4 cell count ≥200 cells/mm3 was associated with better renal function after 2 years of follow-up.


Sujets)
Humains , Mâle , Femelle , Adulte d'âge moyen , Infections à VIH/complications , Insuffisance rénale chronique/virologie , Protéinurie/sang , Facteurs temps , Biopsie , Sérumalbumine , Modèles des risques proportionnels , Valeur prédictive des tests , Études rétrospectives , Néphropathie associée au SIDA/anatomopathologie , Statistique non paramétrique , Évolution de la maladie , Numération des lymphocytes CD4 , Charge virale , Insuffisance rénale chronique/anatomopathologie , Débit de filtration glomérulaire , Glomérulonéphrite/anatomopathologie
3.
Braz. j. med. biol. res ; 22(10): 1295-301, 1989. tab
Article Dans Anglais | LILACS | ID: lil-83393

Résumé

The effects of cisplatin on renal microcirculation were evaluated in euvolemic Munich-Wistar rats submitted to micropuncture. Nine rats received a single dose of cisplatin (6 mg/kg,ip), and 6 control rats received the same volume (0.3 ml) of 15 mM NaCl 4 days before the measurements. Cisplatin administration induced non-oliguric acute renal failure by decreasing glomerular filtration rate (GFR) from 0.96 + or- 0.5 to 0.33 + or - 0.04 ml/min (P<0.05) and by increasing urinary volume from 3.3 + or - 0.3 to 12.4 + or - 2.2 micronl/min (P<0.05). Cisplatin administration decreased single nephron GFR from 34.2 + or - 2.1 to 20.1 + or - 2.3 nl/min (P<0.05) due to a reduction in both glomerular plasma flow from 106 + or - 9 to 61 + or - 6 nl/min (P<0.05) and transcapillary hydraulic pressure difference from 31 + or - 1 to 27 + or - 1 mmHg (P<0.05). An increase in arteriolar resistances, mainly afferent arteriolar resistance from 2.5 + or - 0.2 to 4.7 + or - 0.5 x 10**10 dyn.s.cm**-5 (P<0.05), was observed. The glomerular ultrafiltration coefficient was unchanged


Sujets)
Rats , Animaux , Mâle , Circulation rénale , Cisplatine/pharmacologie , Débit de filtration glomérulaire , Cisplatine/administration et posologie , Insuline , Inuline , Microcirculation , Ponctions , Lignées consanguines de rats , Perte de poids/effets des médicaments et des substances chimiques
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